Diabetes Flashcards
What is the MOA of GLP-1/GIP agonists?
analog of incretin hormone GLP-1/GIP –> GLP-1/GIP increases glucose-dependent insulin secretion, decreases glucagon secretion, and slows gastric emptying which improves satiety and promotes weight loss
What are boxed warnings with GLP-1/GIP?
Risk of thyroid C-cell carcinomas; do not use if personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome 2 (not Byetta)
What are warnings with GLP-1/GIP?
- pancreatitis, AKI, gallbladder disease
- not recommended in patients with severe GI disease, including gastroparesis
What are warnings with Bydureon?
serious injection site reactions with or without nodules
What are the warnings with Ozempic, Trulicity, and Mounjaro?
increased complication with diabetic retinopathy
What are SEs with GLP-1/GIP?
- weight loss
- N/V/D (reduced with dose titration)
- hypoglycemia
- injection site reactions
What is a side effect specific to Tirzepatide?
increased HR
What drug class should GLP-1/ GIP not be taken with?
DPP-4 inhibitors
Liraglutide
Victoza
Saxenda (weight loss)
Dulaglutide
Trulicity
Semaglutide
Ozempic
Wegovy (weight loss)
Rybelsus PO
Exenatide
Byetta
Exenatide ER
Bydureon BCise
How often is liraglutide given SQ?
daily
How often is dulaglutide given SQ?
weekly
How often is semaglutide given SQ?
weekly
How often is semaglutide given PO?
daily
How often is exenatide given SQ?
BID