Diabetes Flashcards
diabetes mellitus refers to
a group of diseases
disorder metabolism with _____ due to deficiency of _____
inapprop evalated glucose (hyperglycemia), insulin and/or insulin resistance
what are the 5 main groups
- type 1
- type 2
-monogenic forms of diabetes
-gestational diabetes - secondary diabetes
type 1 diabetes
autoimmune disease destroys b-cells
type 2 diabetes
many different genetic and environmental contributors; intially failure of cells to adequately respond to insulin by lowering glucose (insulin resistance) causes high insulin secretion, but in later stages there is impaired insulin biosynthesis/secretion by b-cells
monogenic forms of diabetes
- ie neonatal diabetes
- individuals cannot produce enough insulin, usually due to a single gene mutation
gestational diabetes
develops or is recognized during pregnancy
secondary diabetes
damage to the pancreas, or excess levels of other hormones, drugs, etc
what % of people have type 1 diabetes
10%, 1-2% out of 10,000 in a population
Type 1 Diabetes
autoimmune diease…
- Autoimmune disease that destroys β cells
process can extend over months or years