diabete treatment doses

Question 1

what is the dose of metformin?

Answer 1

500mg initially once daily for atleast a week - taken with breakfast.
THEN increased 500mg TWICE daily for atleast a week - taken with breakfast and evening meal
THEN increased 500mg THREES TIMES daily with each meal

MAX 2g daily

Question 2

what can you combine metforming with?

Answer 2

• a sulfonylurea
• Pioglitazone;
• dipeptidylpeptidase-4 inhibitor
• a sodium glucose co-transporter 2 inhibitor only when sulfonylureas are contra-indicated or not tolerated, or if the patient is at significant risk of hypoglycaemia or its consequences.

Question 3

what is the dose of sulfonylureas?

Answer 3

Glipizide Initially 2.5–5 mg daily, adjusted according to response (max 20mg)

Question 4

what is the dose of meflitonides?

Answer 4

Repaglinide 0.5-4mg with meals

Nateglinide 60-120mg with meals

Question 5

what is the dose of DPP 4 inhibitors?

Answer 5

Linagliptin 5 mg once daily

Question 6

what is the dose of GLP 4 inhibitors?

Answer 6

For Saxenda®
Initially 0.6 mg once daily, then increased in steps of 0.6 mg, dose to be increased at intervals of at least 1 week; consider discontinuation if escalation to the next dose is not tolerated for 2 consecutive weeks. Discontinue if at least 5% of initial body-weight has not been lost after 12 weeks at maximum dose; maximum 3 mg per day.

Question 7

what is the dose for pioglitazone?

Answer 7

Initially 15–30 mg once daily, adjusted according to response to 45 mg once daily, in elderly patients, initiate with lowest possible dose and increase gradually; review treatment after 3–6 months and regularly thereafter.