Devpt Of Multicell Organisms 1 Flashcards

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1
Q

What does it mean for cells to have a memory?

A

They retain record of signals their ancestors received during embryonic development.

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2
Q

Ectoderm

A

Precursor of the nervous system and the epidermis

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3
Q

Endoderm

A

Precursor of gut, lung and liver

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4
Q

Mesoderm

A

Precursor of muscles and connective tissue

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5
Q

Gastrulation

A

Transformation of a hollow sphere of cells into a structure w/ a gut

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6
Q

What are the two classes of proteins most important for development?

A

Cell adhesion/ cell signaling proteins and Gene regulatory proteins

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7
Q

Where are the instructions for producing a multicellular animal contained?

A

In the non-coding regulatory DNA associated a/ each gene

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8
Q

In DNA, what serves as the biding sites for gene regulatory proteins?

A

Regulatory elements within the DNA; regulatory DNA defines the sequential program for development

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9
Q

What makes one organism different from another and provides uniqueness?

A

Non-coding sequences

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10
Q

When do cells make developmental decisions?

A

Long before they show any outward sign of differentiation

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11
Q

Define “determined”

A

Cells that are fated to develop into a specialized cell type despite changes in environment

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12
Q

Define “completely undetermined”

A

Cells that can change rapidly due to alterations in environment

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13
Q

Define “committed”

A

Cells that have some attributes of a particular cell type but can change with environment

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14
Q

What does it mean for cells to be regionally determined?

A

Before acquiring a particular fate, they express genes that are markers of their location. The position specific character of a cell is called positional value

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15
Q

What are the most important environmental cues?

A

Signals from neighboring cells

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16
Q

Define inductive signaling

A

Induction of a different developmental program in select cells in a homogeneous group leading to altered character

17
Q

Positive feedback

A

System starts homogeneous and symmetrical then the environment imposes weak asymmetry. Positive feedback amplifies this effect. Broken asymmetry is all or none and irreversible

18
Q

What does positive feedback provide the cells with?

A

Memory

19
Q

What is a morphogen?

A

A long range inductive signal that imposes a pattern on a field of cells

20
Q

What is the gradient formed by in morphogens?

A
  1. Localized production of an inducer that diffuses away from its source and 2. Localized production of an inhibitor that diffuses away from its source and blocks the action of a uniformly distributed inducer
21
Q

Signaling pathways

A

Handful of conserved family of proteins; ultimately result of inductive events is change in DNA transcription. Some genes turned on, other turned off. The response depends on spatial and temporal expression of different sets of genes.

22
Q

Signaling pathway: RTK. What are the ligands?

A

EGF; FGF (Branchless); Ephrins

23
Q

Signaling pathway: TGF-beta superfamily. Ligand family?

A

TGFbeta; BMP(Dpp); Nodal

24
Q

Signaling pathway: Wnt. Ligand family?

A

Wnt (wingless)

25
Q

Signaling pathway: Hedgehog. Ligand family?

A

Hedgehog

26
Q

Signaling pathway: Notch. Ligand family?

A

Delta

27
Q

What controls development?

A

Gene expression