Developmental Duplication

Question 1

what bull (in Holstein Friesian breed) is used that causes cattle Citrullinaemia?

Answer 1

Linmack Kriss King

Question 2

Developmental Duplication is common in what breed of cattle?

Answer 2

Angus cattle

Question 3

a neural tube defect; cranial and spinal dysraphism (incomplete fusion)

Answer 3

developmental duplication

Question 4

A condition that causes an additional leg

Answer 4

Polymelia

Question 5

Acephalic conjoined ‘twin’

Answer 5

Axial duplication

Question 6

within Dura of the CNS

Answer 6

intradural teratomas

Question 7

fluid-filled cysts with black hairs;
within dura or extradural

Answer 7

Dermoid cysts and occipital skin flaps

Question 8

fat tissue mass

Answer 8

lipomas

Question 9

mild to severe facial defects;
maxillary brachygnathia;
mandibular prognathia

Answer 9

Craniofacial dysmorphogenesis

Question 10

diprosopus (two faces);
diencephalon (two heads)

Answer 10

Craniofacial Duplications

Question 11

deformed hindlegs with Arthrogryposis

Answer 11

Congenital arthrogryposis and hindlimb deformity

Question 12

spinal cord tethering/ compression;
scoliosis associated with dysraphism (incomplete fusion) and vertebral anomalies

Answer 12

postnatal ataxia

Question 13

high rates of postimplantation embryonic death & resorption

Answer 13

embryonic deaths

Question 14

aka curly calf syndrome

Answer 14

arthrogryposis multiplex

Question 15

congenital contracture and fixation of multiple joints

Answer 15

arthrogryposis multiplex

Question 16

water head;
severe hydrocephalus –> cardiomegaly;
heritable recessive disorder

Answer 16

Neuropathic Hydrocephalus

Question 17

aka Fawn calf syndrome;
Marfanoid syndrome;
elongated limbs;
kyphosis (congenital contractures of the spine;
proximal joints of hindlimb;
muscular hypoplasia

Answer 17

Congenital Contractual Arachnodactyly

Question 18

Miniature Angus calf;
smaller for gestational age from conception;
poor growth;
cryptorchid male –> infertile

Answer 18

Proportionate dwarfism

Question 19

1 or more forms of Dwarfism;
mild chondrodysplasia;
potbelly;
thick/blocky shape;
elongated nose/ short face

Answer 19

Disproportionate Dwarfism

Question 20

Dexter cattle;
short-legged phenotype;
heterozygous for Bulldog calf;
in utero death;
micromelia (abnormally small extremities);
tongue protrusion;
short vertebral column and ribs

Answer 20

Dexter chondrodysplasia

Question 21

Severe fetal dystocia;
hydrops fetalis (fluid buildup in tissues and organs) OR anasarca (swelling of whole body);
pulmonary aplasia (failure of development of the primitive lung bud);
absence of lung tissue

Answer 21

pulmonary hypoplasia and anasarca

Question 22

pulmonary hypoplasia and anasarca is common in what breed of cattle?

Answer 22

Dexter cattle;

Question 23

congenital lethal malformation;
23% fetal mortality;
bilateral flexion of carpal & metacarpophalangeal joints;
digit rotation

Answer 23

complex vertebral malformation syndrome

Question 24

complex vertebral malformation syndrome is common in what cattle breed?

Answer 24

Holstein-Friesian

Question 25

complex vertebral malformation syndrome is the single base mutation of ___

Answer 25

SLC35A3

Question 26

Congenital, lethal;
Birth weight reduction to 10 kg;
shortening of spine;
long, slender limbs;
inferior brachygnathism;

Answer 26

Brachyspina

Question 27

brachyspina is common in what cattle breed?

Answer 27

Holstein-Friesian

Question 28

Brachyspina is the mutation of what gene?

Answer 28

FANCI (Fanconi anemia, complementation group I)