Developmental biology Flashcards
over the course of 9 months, a human zygote undergoes ___, ____ and _____ in preparation for life outside the uterus
cell division, cellular differentiation and morphogenesis
2 early developmental stages
fertilization and cleavage
when does fertilization occur in mammals?
12-24 hours after ovulation
where does fertilization occur?
in the lateral, widest portion of the oviduct where sperm travelling from the vagina encounter an egg
what may result from the fertilization of more than one egg?
fraternal (dizygotic) twins may be conceived
What occurs when one zygote divides into two separate embryos?
identical (monozygotic) twins
early embryonic development is characterized by a series of rapid mitotic divisions known as ____
cleavage
during cleavage, what happens to the total volume of the cytoplasm?
it remains constant
cleavage results in progressively smaller cells with an increasing ratio of ___ to ___
nuclei to cytoplasm
When do the first, second, and third complete cleavage of zygote occur?
1st: approx 32 hours after fertilization
2nd: approx 60 hours “”
3rd: approx 72 hours “”
how many cells are present following 3 complete cleavages of the zygote?
8
define morula
once embryo reaches the uterus, cell division continues and forms a SOLID BALL OF EMBRYONIC CELLS known as morula
What is blastulation?
process by which a morula develops a fluid-filled cavity called the BLASTOCOEL, which by the fourth day becomes a hollow sphere of cells called the BLASTULA
What is the name of the stage of the embryo which implants in the uterus?
blastula
What occurs in an ectopic pregnancy?
embryo implants outside the uterus (e.g., in the Fallopian tube)
Describe gastrulation
After week 2, the embryo is fully implanted in the uterus and cell migrations transform the single cell layer of the blastula into a THREE-LAYERED STRUCTURE called a GASTRULA
3 primary germ layers:
- ectoderm
- endoderm
- mesoderm
what structures does each primary germ layer give rise to?
- ectoderm: INTEGUMENTARY SYSTEM (including the EPIDERMIS, hair, nails, and epithelium of the nose, mouth, and anal canal), the LENS OF THE EYE, the RETINA, and the NERVOUS SYSTEM.
- endoderm: EPITHELIAL LININGS OF THE DIGESTIVE AND RESPIRATORY TRACTS (including the lungs) and parts of the LIVER, PANCREAS, THYROID, and BLADDER LINING
- mesoderm: MUSCULOSKELETAL SYSTEM, CIRCULATORY SYSTEM, EXCRETORY SYSTEM, GONADS, CONNECTIVE TISSUE THROUGHOUT THE BODY, and portions of the DIGESTIVE and RESPIRATORY ORGANS.
define neurulation
neurulation occurs after gastrulation and is the process by which regions of the germ layers begin to DEVELOP INTO A RUDIMENTARY NERVOUS SYSTEM
When does neurulation occur?
before week 3
The rod of ______ cells is called the notochord
mesodermal
what kind of effect does the notochord have on the overlying ectoderm? What occurs?
the notochord has an INDUCTIVE EFFECT on the overlying ectoderm, causing it to BEND INWARD and form a GROOVE along the dorsal surface of the embryo.
The dorsal ectoderm FOLDS on either side of the tube, forming the NEURAL TUBE