Development of the Nervous System Flashcards
What is the name given to the proliferation of the ectoderm in the dorsal midline?
Neural plate
What happens to the neural plate as it thickens?
It folds up the sides and eventually the two neural folds fuse to form a tube
The space in the middle is the neural canal
What is the name given to the bunch of cells at the tip of the neural fold that are excluded in the fusion?
Neural crest
Which cells do the neural tube and neural crest cells give rise to?
Neural tube – all cells of the CNS Neural crest – all cells of the PNS
What is the name given to the wall of the neural tube?
Neuroepithelium
What three types of cells do neuroepithelium give rise to?
Neuroblasts – all cells with cell bodies in the CNS
Glioblasts – these become neuroglia (astrocytes + oligodendrocytes)
Ependymal cells – line the ventricles and the central canal
Are motor neurons produced from neuroepithelium?
Yes – although most of their axons are outside the CNS, their cell bodies are within the spinal cord
State four cell types that neural crest cells can differentiate into.
Sensory neurons of dorsal root ganglia and cranial ganglia Autonomic post-ganglionic neurons Schwann cells Non-neuronal cells e.g. melanocytes
Describe the arrangement of the neuroepithelium.
Neuroepithelium has an inner layer and an outer layer Most cells are connected to both the inner and outer layer but the nuclei are at different positions
Describe the differentiation of the neuroepithelium.
Firstly, you get cells withdrawing away from the outer membrane towards the inner membrane where it undergoes mitosis One of the daughter cells will remain attached to the inner membrane and the other daughter cell will move away from the inner membraneand become a neuroblast The neuroblast will develop processes and one will become the axon These axons are directed away from the inner membrane Three layers are formed
What are the three layers formed by the differentiation of the neuroepithelium?
Ependymal, grey matter and white matter
AKA germinal layer, mantle layer, marginal layer respectively
Glioblasts show a similar pattern of differentiation to neuroblasts. State one difference.
Glioblasts can migrate into the white matter NOTE: glioblasts do not develop axons (but they do develop processes)
What guides the process of differentiation and migration?
Signalling molecules
Which factors are important with regards to signalling molecules?
Concentration and timing
What can the grey matter of the neural tube be divided into?
Alar plates aka roof plate (dorsal)
and basal plates aka floor plate (ventral)
Which types of neurons do the alar plate and basal plate give rise to?
Alar plate – interneurons
Basal plate – interneurons and motor neurons
Which structures around the neural tube release signalling molecules and what effect do they have on the cells in the neural tube?
Notochord and ectoderm Notochord releases signalling molecules that induce the cells nearest to it to differentiate into motor neurons Ectoderm produces signalling molecules that inhibit the cells nearest to it from differentiating into motor neurons
Around 4 weeks, you get differentiation of the wall of the anterior neural tube to form three primary vesicles. Name these primary vesicles.
Prosencephalon – future forebrain Mesencephalon – future midbrain Rhombencephalon – future hindbrain
Describe the changes that occur to these three vesicles in the week or so following their formation.
The first and third vesicles divide in two Prosencephalon -telencephalon + diencephalon Rhombencephalon - pons + medulla
What important structure begins to appear quite late in development (around 8 weeks) and where does it appear from?
Cerebellum – appears as an out pouching from the back of the pons
Name the three flexures in the developing brain.
Cephalic
Pontine
Cervical
Describe the formation of the 4th ventricle.
In the neural tube in the region that will become the brainstem, the roof plate rapidly proliferates and causes the alar plates to split apart so that they are lateral to the roof plate The space left from the proliferation of the roof plate will become the 4thventricle
Describe the arrangement of motor, sensory and autonomic cranial nuclei within the brainstem.
Motor = medial
Sensory = lateral
Autonomic = in between
What structure divides the motor nuclei from the sensory nuclei in the brainstem?
Sulcus limitans
How do neuroblasts migrate from the inner membrane to the outer membrane in the brain?
They attach themselves to radial glial cells and climb up them towards the outer membrane Radial glial cells have their cell bodies anchored to the inner membrane and have a single long process to the outer membrane
What happens to neuroblasts that stay in the middle of the cortex?
They become the basal ganglia
How many layers of cells are there within the cerebral cortex?
SIX
What can a deficiency of folic acid in pregnancy lead to?
Spina bifida
(and potentially anenchephaly)
folic acid is normally given a few weeks before conception to avoid this
