Development of the Muscular System Flashcards

1
Q

Mesoderm forms into paraxial, intermediate and lateral plate mesoderm… what does paraxial form?

A

Paraxial forms somites which forms the myotome ( all muscle but pupil), sclerotome (skull/vertebral column), and dermtome (dermis)

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2
Q

What does the intermediate mesoderm (next to paraxial) form?

A

the urogenital system (including kidneys and gonads)

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3
Q

What does the lateral plate form (somatopleure and splanchnopleure)?

A

Connective tissue including blood, lymph, mesenteries and cardiovasuclar

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4
Q

The somite can be divided into two parts, dorsal lateral and ventral medial, what do they become?

A

Ventral medial becomes the sclerotome and dorsal lateral top part becomes the dermatome and bottom half becomes the myotome

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5
Q

Where does the sclerotome go once it is cut into the ventral medial part?

A

Migrates down to notochord and around the neural tube to help form vertebral body

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6
Q

What does the sclerotome form and what does that become?

A

mesenchyme (mesoderm), which is embryonic connective tissue

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7
Q

What are the two different ways to make bone from mesenchyme?

A

intramembranous ossification and endochondral ossification

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8
Q

How is bone made by intramembranous ossification, examples?

A

The mesenchyme is in the shape of the bone it wants to become and then becomes it (flat bones parietal, frontal, face bones)

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9
Q

How is bone made by endochondral ossification, examples?

A

Mesenchyme forms hyaline cartilage in the shape of the bone and then forms the bone (Long bones (femur, humerus, pelivis, etc))

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10
Q

What cartilage precursor is used to form most of the bones in your body?

A

Hyaline cartilage: is a chondrification center which goes to prechondrocytes, to chondroblasts, to chondrocytes (later)

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11
Q

What are the two components of the sclerotome when forming the vertebral column, as well as other players?

A

Caudal dense part (lower hlaf) Cephalic losse part (upper half) each set of losse/dense parts have a myotome to form the muscles, as well as dermotome, and surface ectoderm

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12
Q

What occurs to form the beginning of the vertebral column?

A

The cephalic loose sclerotome will migrate up to meet with caudal dense, and caudal dense will migrate down to meet with loose.

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13
Q

After fusing dense and loose sclerotome, what happens to the myotome?

A

It migrates and connects the upper vertebrae and lower vertebrae, instead of muscle on one bone

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14
Q

How do nerves get made during the formation of the vertebral column?

A

The spinal cord connects to the muscle to form the nerves/ motor neurons (week 3/4!)

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15
Q

Where are the intersegmental arteries located after the formation of the vertebral cloumn?

A

They are on the sides of the vertebrae

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16
Q

What components of the vertebra come from cephalic loose and caudal dense parts?

A
17
Q

What are the 2 parts of the intervertebral discs, and how are they made?

A

Nucleus Pulposus: from degenrating notochord

Annulus Fibrosis: from fibrocartilage from sclerotome

18
Q

How are the ribs and costal cartilage formed?

A

From the sclerotome that grow out of the costal processes of thoracic vertebrae

19
Q

How is the sternum formed?

A

Comes from the somatic layer of the lateral plate mesoderm, starts as sternal bars and fuse to form sternum

20
Q

What occurs when there is a cervical rib that is formed during development?

A

Causes thoracic outlet syndrome, which can compress the subclavian artery/nerve

21
Q

What is pectus carinatum?

A

Pigeon chest! (zach Greene) sternum protrudes, more pronounced as getting older (more boys)

22
Q

What is pectus excavatum?

A

funnel chest! sternum depression, compresses heart and shift to left side: can’t breathe, exercise intolerance

23
Q

What are hox genes?

A

group of genes that control the body plan along a cranio-caudal axis

24
Q

What happens to hox genes when there is caudalization TAIL (gain of function)?

A

If there is an overexpression of Hox 6 in C vert, it will overexpress and change C vertebra to look more like vertebra below (T)

25
Q

What is cranialization HEAD (loss of function) of hox genes and what occurs?

A

lose Hox 4 in C2, vertebrae will look like C1, if lose Hox 5 (C3-T2) will look like C2,

26
Q

What does Hox 9 express?

A

Floating ribs

27
Q

What are the hox genes that signal for formation of different vertebra?

A

Hox 4,5,6,9,10,11 (from C → Sacral)

28
Q

What two parts does the myotome divide into?

A

Epimere and Hypomere

29
Q

What does the epimere form?

A

Epaxial muscles (back muscles) innervated by dorsal rami (ramous)

30
Q

What does the hypomere form?

A

Hypaxial muscles (all other muscles) innervated by ventral rami

31
Q

What allows for the flexion and extension of limbs and shoulders?

A

Hypaxial muscles

32
Q

Mucles derived from mytomal epaxial divisions?

A

extensor muscles of neck ,vertebral column and back

33
Q

Cervical myotomes (hypaxial division) give rise to?

A

scalene, prevertebral, geniohyoid, and infrahyoid muscles

34
Q

Thoracic myotomes (hypaxial division) give rise to?

A

lateral and ventral flexor muscles of vertebral column

35
Q

Lumbar myotomes (hypaxial division) give rise to?

A

Quadratus lumborum

36
Q

Sacrococcygeal myotome (hypaxial division) give rise to?

A

pelvic diaphragm

37
Q

What is poland syndrome and how does it occur?

A

absense of migration of cells of hypomere into chest: not pectoralis major/minor, sometimes missing ribs

38
Q

What is Prune-belly syndrome and how does it occur?

A

Partial/complete absence of abdominal musculature due to absense of migration of hypomere into abdomen… **males**, can include cryptorchidism (testes don’t descend) and malformation of urinary tract