Desquamative Gingivitis Flashcards

1
Q

What is characterized with chronic desquamative gingivitis?

A

intense erythema, desquamation, ulceration of free and attached gingiva

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

T/F: Chronic desquamative gingivitis always show symptoms.

A

False. They can be asymptomatic, mild burning to intense pain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Where is chronic desquamative gingivitis usually located?

A

50% localized to gingiva but can also have intra or extra oral sites

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is the genesis of chronic desquamative gingivitis?

A

Dermatologic Genesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is the usual patient of a someone with chronic desquamative gingivitis?

A

40-50 year old female

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What can Lichen Planus affect?

A

oral cavity, genital tract, mucosa, skin, scalp, nails

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What cells play a major role in Lichen Planus?

A

T lymphocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is a possible etiology of Lichen Planus?

A

reaction to adjacent restoration

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

How common is Lichen Planus?

A

0.1% to 4%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What are the most common types of Lichen Planus?

A

Reticular and Erosive

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is common in Reticular Lichen Planus?

A
  • Wickham strae (white lines)
  • bilateral
  • asymptomatic
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is common in Erosive Lichen Planus?

A
  • Wickham strae (white lines)
  • ulceration
  • painful
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Compare/contrast reticular vs erosive Lichen Planus.

A

similar: both have Wickham strae (white lines)
difference: erosive is painful

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is common in histopathology of Lichen Planus?

A
  • T lymphocytes in lamina propria in abundance
  • hydrophic degeneration
  • colloid bodies at epithelium
  • “saw tooth”
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What can you see with immunofluorescence in Lichen Planus?

A

fibrin and cytoid deposit

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is the treatment of Lichen Planus?

A

asymptomatic= nothing
lesions= 0.05% flucinonide gel and clotrimazole 10 mg

17
Q

What is common in Pemphigoid?

A

cutaneous, separation between epithelium and connective tissue junction

18
Q

What’s the difference between bollous and cicatricial pemphigoid?

A

bollous= no scarring
cicatricial= scarring

19
Q

How common is pemphigoid in oral lesions?

A

40%

20
Q

What can you see in immunofluorescence in pemphigoid?

A

immunoglobulin G. complement 3, sometimes other immunoglobulins, fibrin deposits

21
Q

What is the treatment for pemphigoid?

A

corticosteroids (prednisone) and immunomodulator drugs

22
Q

Where can cicatrical/mucous membrane pemphigoid affect?

A

anywhere there is mucous a membrane

23
Q

What is symblepharon?

A

scarring resulting in adhesion between eyelid and eyeball seen in cicatrical/mucous membrane

24
Q

What is ankyloblepharon?

A

scarring resulting in adhesion at edges of eyelids

25
Q

How long is the cycle of pemphigoid oral lesion?

A

the bullae take 2-3 days to rupture after forming which then leave an ulceration
healing takes 3 or more weeks

26
Q

What is the treatment of pemphigoid oral lesion?

A

0.05% fluocinonide gel and clobetasol propionate

27
Q

What is the difference in separation between pemphigoid and pemphigus vulgaris?

A

pemphigoid= separates between epithelium and connective tissue (sub epithelial)
pemphigus vulgaris= separates between the 2 epithelial layers
(intra epithelial)

erythema multiform can be intra or sub epithelial

28
Q

What is etiology of pemphigus vulgaris?

A
  • antibiotics and other drugs
  • autoantibody to cadherin-type epithelial cell adhesion molecules
29
Q

What is most often involved in the oral cavity for pemphigus vulgaris?

A

soft palate (80%)
then buccal mucosa (46%) , then tongue (20%) , then lower labia mucosa (10%)

30
Q

What are key identifiers for pemphigus vulgaris?

A
  • “tombstone” appearance in histopath
  • strawberry gingivitis
  • intra epithelial
31
Q

What do you give to treat chronic ulcerative stomatitis?

A

hydroxychloroquine because it’s not responsive to corticosteroid treatment

32
Q

What are the clinical presentations of lupus erythematosis?

A

systemic, chronic, and cutaneous

lesions are similar to lichen planus

33
Q

What is a key feature in erythema multiform?

A

target/iris lesion

34
Q

What is the later form of erythema multiform?

A

Stevens-Johnson syndrome which effects every mucosa of your body

35
Q

What is etiology of erythema multiform?

A

unknown but thought to be caused by cytotoxic immune reaction

36
Q

What is the histopathology of erythema multiform?

A

can be sub or intra epithelial

37
Q

What is the treatment of erythema multiform?

A

antihistamines, topical anesthetics (for pain), plaque control, systemic corticosteroids