desmopressin

Question 1

what is the classification of desmopressin?

Answer 1

posterior pituitary hormone regulator

Question 2

what is the pharmacotherapeutic (use) for desmopressin?

Answer 2

manage central DI (diabetes insipidus) and noctural emesis and maintain homeostasis in hemophilia A
intranasal form used for treating autonomic failure characterized by poly nocturia, postural hypotension, overnight weight loss

Question 3

how is desmopressin administered?

Answer 3

intranasally, orally or parenterally (IV or SQ)

Question 4

what are the pharmacodynamics of desmopressin?

Answer 4

interact with V1 and V2 receptors to create general constriction of smooth muscle.

Question 5

what are the contraindications and precautions of desmopressin?

Answer 5

hypersensitivity. use with caution for those with electrolyte imbalances or renal disease

Question 6

what are the adverse effects of desmopressin?

Answer 6

abdominal pain, transient HA, nasal congestion, nausea, rhinitis, and facial flushing

Question 7

what are the drug interactions of desmopressin?

Answer 7

carbamazepine, chlorpromazine, and nonsteroidal anti-inflammatory drugs all enhance antidiuretic response to vasopressing, thus, these drugs may potentiate the effects of desmopressin

Question 8

what are the health status, lifespan/gender, lifestyle/diet/habits & environment of desmopressin?

Answer 8

• assess for condition that require drug therapy. use caution for pts with vascular disease. assess for confusion, drowsiness, listlessness, HA
• pregnancy category B
• assess lifestyle activities and use of recreational drugs which may stimulate secretion of ADH
• assess environment where drug will be given.

Question 9

how do you maximize the therapeutic effects of desmopressin?

Answer 9

• establish baseline values for weight, BP, electrolytes, and urine specific gravity
• protect ADH solutions from agitation and temperature extremes.

Question 10

how do you minimize the adverse effects of desmopressin?

Answer 10

assess the pt for pre-existing cardiovascular or renal disorders and monitor pts carefully for cardiac reactions from desmopressin

Question 11

what are the patient and family education of desmopressin?

Answer 11

• provide information about drug therapy
• alcohol can alter the therapeutic response to desmopressin
• a decrease in phosphate causes an indirect effect on PTH by combining with calcium and decreasing serum calcium concentrations.