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DERMATOLOGY Premade cards > DermPath > Flashcards

DermPath Flashcards

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Dermatology Board Prep flashcards
1
Q

diagnosis of epidermal tumors slammed up against the epidermis

A

S- scc (keratin +)
L- leomyosarcoma (desmin +, smooth muscle actin)
A- afx
M- melanoma (s100+)

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2
Q

Differences between KA and SCC

A

KA - never acantholysis, has neutrophil microabcesses, eos, and collagen trapping

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3
Q

Pagets Disease immuno markers

A

CK7+
S100-
CEA +
PAS+, diastase negative bc of sialomucin (difference from Bowens which is diastase positive)

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4
Q

multiple pilomatricomas are associated with which disease?

A

Myotonic Dystrophy

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5
Q

Stains strongly in BCC

A

BCL-2

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6
Q

Which two paisley tie tumor dx do you see horn cysts in?

A

Desmoplastic Tricho ep

MAC

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7
Q

What do desmoplastic trichoeps have that none of the other paisley tie tumors have?

A

calcification

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8
Q

syringomas look like what on physical exam and are common in whom?

A

Red small papules on the lower lids, common in downs patients

on path are a paisley tie tumor with no horn cysts calcification or perinueral invasion

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9
Q

Fibrofolliculoma is the same this as:

A

Trichodiscoma

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10
Q

Multiple fibrofolliculomas, trichodiscomas, acrochordons

A 
Birt-Hogg-Dube
(likely they are all the same thing)
\+chromophobe RCC
\+renal oncocytomas
\+spontaneous pneumothorax
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11
Q

Kamino bodies

A

Spitz Nevus

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12
Q

translocation in clear cell sarcoma

A

(t12,t22)(q13,q12)

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13
Q

ddx of collections of neutrophils within the stratum corneum:

A

Psoriasis, tinea, candida, syphilis, seb derm, impetigo

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14
Q

Diagnoses with plasma cells:

A 
Syphilis 
Kaposis
Leichmeniasis
Squamous cell
Melaonma
Rhinoscleroma
Tuberculosis
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15
Q

What is the pneumonic for spongiosis with eos? and what does is stand for

A 
HAAPIE
Herpes gestationis
arthropod bite
allergic contact derm
pemphigus
pemphigoid 
incontia pigmenti
e tox
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16
Q

Subcorneal split

  • essentially in the granular layer
  • dsg-1
A

Pemphigus folieceous

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17
Q

Medlar bodies

A

copper pennies in Chromoblastomycosis

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18
Q

“chain of coins, or brass knuckles”

A

Lobomycosis

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19
Q

deep fungal inx associated with dolphins

A

Lobomycosis

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20
Q

Splendore-Hoeppli phenomenon

A

yeast cell surrounded by eosinophilic fringe (also known as Asteroid body)

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21
Q

thick walled spherules loaded with endospores

A

Coccidiodomycosis

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22
Q

broad based budding

A

Blastomycosis

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23
Q

Mariners wheel

A

PUaracoccidiodomycosis (south american blastomycosis)

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24
Q

Morula

A

Protothecosis

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25
Q

Which is positive for which (DFSP vs DF)

  • CD34
  • Factor XIIIa
A

DFSP - CD34 (has abt 34 letters)

DF- Factor XIIIa (has abt 13 letters)

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26
Q

Which is positive for which (DFSP vs DF)

  • CD34
  • Factor XIIIa
A

DFSP - CD34 (has abt 34 letters), factor XIIIa negative

DF- Factor XIIIa (has abt 13 letters), CD34 negative

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27
Q

What spindled tumor is CD68+?

A

AFX

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28
Q

Conditions in which you find angiod streaks

A 
P-penacillamine
E- ehlers danlos
P- PXE
S- sickle cell
I- increased phosphate
L- lead poisoning
T- thalessemia
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29
Q

Conditions with spongiosis with eosinophils:

A 
H- herpes gestationis
A- allergic contact derm
A- arthropod 
P- pemphigoid
P- pemphigus
I- incognitia pigmenti
E- e tox
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30
Q

Conditions with spongiosis with eosinophils:

A 
H- herpes gestationis
A- allergic contact derm
A- arthropod 
P- pemphigoid
P- pemphigus
I- incognitia pigmenti
E- e tox
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31
Q

Stains for mast cells

A

Leider
Toltidine blue
Giemsa
CD117

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32
Q

Epitheliod Sarcoma histo markers

A

Vimentin
Pankeratin
EMA (Epithelial membrane antigen)

*epitheliod sarcomas has features of an epithelial cells and of sarcoma cells

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33
Q

Culture medium used for Mycobacteria

A

Lowenstein-Jensen

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34
Q

Culture medium for Neisseria Gonorhhea

A

Chocolate agur

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35
Q

Culture medium for staph or strep

A

Sheep blood agar

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36
Q

Russel Bodies

A

Plasma cells with immunoglobulin within them
Found in:
Rhinoscleroma
&Granuloma inguinale

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37
Q

Donovan bodies

A

Granuloma inguinale

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38
Q

DDs for PEH with pus:

A

Here Come Big Green Leafy Veggies

Halogenoderma
Chromomycosis
Blastomycosis
Granuloma inguinale
Leichmeniasis
V pemphigus vegetans
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39
Q

Globi found in the dermis

A

Lepromatous Leprosy

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40
Q

Donovan bodies

A

Granuloma inguinale (organisms within histiocytes)

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41
Q

Mycobacteria (Lepromatous Leprosy) stain well with:

A

Fite stain

*NOTE= tuburculoid leprosy does not stain well with Fite stain

42
Q

Guaneri bodies

A

Smallpox

43
Q

The presence of which types of cells help distinguish LyP from PLEVA?

A

CD30+ cells (present in LyP but not PLEVA)

44
Q

Name two endothelial cell markers

A

CD31, CD34

45
Q

What stain is used to identify cells of mesenchymal origen?

A

Vimentin

46
Q

What finding clinches the diagnosis for infantile digital fibroma?

A

Pink Red inclusions within cells

47
Q

Finding: pink/red inclusions within cells of a big pink dermal ball

A

Infantile digital fibromatosus

48
Q

Pustulo-ovoid bodies of Milan

A

Granular cell tumor

49
Q

Virchow cells

A

Lepromatous leprosy

50
Q

Sudan III stain

A

Used to stain Virchow cells in lepromatous leprosy

51
Q

What stain do you use to stain Virchow cells in leprosy

A

Sudan III stain

52
Q

Most common stain for leprosy

A

Fite stain

53
Q

Does a DF stain for:

  1. CD34
  2. Factor XIIIa
A

CD34- (This is positive in DFSP)

Factor XIIa +

54
Q

What will a DF stain with?

A

Factor XIIIa +

CD34-

55
Q

Variant of DFSP with melanin in it

A

Bednar tumor

56
Q

Stains of an AFX

A

S186+
CD10+
Procollagen+

57
Q

What does a cellular neurothekeoma stain with?

A

PGP9.5

58
Q

What does PGP9.5 stain?

A

Cellular neurothekeoma

59
Q

Leukemia with following features:

  • bland chromatin (blasts)
  • box car (cells lined up splaying the collagen)
A

Myeloid Leukemia (leukemia cutis)

60
Q

Classic markers for MF

A

CD3+, CD4+, CD7-

61
Q

Name the site of each b cell lymphoma clinically:

  1. Marginal zone
  2. Follicle center
A
  1. Marginal zone - extremities

2. Follicle center - head and neck (like a lollipop)

62
Q

3 Ls of inflammation around the eccrine glands

A

Lupus (lymphocytes or plasmas)
Lymphoma
Lichen Striatus

AND BUGBITE (must have eos)

63
Q

Von Kossa stains what

A

Calcium

64
Q

Ber-Ep4 is positive in what type of tumor?

MAC or Desm BCC

A

BCC/Desmo trichoep

Negative in MAC

65
Q

What stain is used to distinguish MAC from BCC or Desmo trichoep

A

Ber-Ep4 (positive in BCC/Trichoep, negative in MAC)

66
Q

T/F NLD has mucin deposition

A

False - it does not!

67
Q

Path stain for mucin

A

Alcian blue
Colloidal iron
Toluidine blue

68
Q

Characteristic immunohistochemical finding in Pagetoid Reticulosis

A

CD45- (pagetoid reticulosis is a rare type of CTCL found as scaly lesions on the hands and feet)

69
Q

Merkel cell tests positive for what stain

A

Cytokeratin 20

(Also for CAM5.2, NSE, chromogranin, synaptophysin)

S-100 negative*

70
Q

Neurofilament stain is positive in everything nerve related except:

A

Schwannoma

71
Q

Osteoclastic giant cells found in:

A

Giant cell tumor of the tendon sheath (no epi)
&
NXG

72
Q

What part of the hair follicle is a trichelomma derived from?

A

Outer root sheath (glycogen derived)

73
Q

What cell type differentiates LyP from PLEVA?

A

Eos! (In LyP)

74
Q

Kamino bodies

A

Spitz

*will never have kamino bodies in melanoma

75
Q

Histologic findings in morphea, that are different from NSF and scleromyxedema

A

Morphea has plasma cells
Trapped eccrine glands
Morphea has a reduced number of CD34+(unlike scleromyxedema or NSF)

76
Q

Reduced number of CD34+ cells

A

Morphea

77
Q

Characteristic staining pattern of nodular amyloid

A

Green birefringence under polarized light with Congo red stain

78
Q

Is amyloid diastase resistant or positive?

A

Resistant

79
Q

What type of protein is macular and lichen amyloid derived from?

A

Keratinocyte derived (vs nodular amyloid which is AL light chain derived)

80
Q

Which is the only cutaneous amyloidosis that is NOT keratinocyte derived?

A

Nodular amyloid

81
Q

Clinical findings of each of the following:
Lichen amyloid
Macular amyloid
Nodular amyloid

A

Lichen amyloid: highly pruritic shiny flat topped papules on the shins
Macular amyloid: hyperpigmented small firm papule with rippled appearance coalescing into plaque in the interscapular area
Nodular amyloid: single or multiple waxy nodules with purpura on the extremities

82
Q

Primary systemic amyloidosis due to what type of protein?

A

AL (light chain)

83
Q

Primary systemic amyloid due to what cause mainly?

A

Multiple Myeloma

84
Q

Secondary Systemic amyloid due to what type of protein

A

AA (non-immunoglobulin protein; amyloid associated protein)

85
Q

Type of amyloidosis due to chronic inflammation, rheumatoid arthritis, TB, periodic fever syndromes like TRAPS Muckle Wells ect

A

Secondary systemic amyloid

86
Q

The 5 L’s of eccrine gland inflammation

A 
Lues (syphilis) 
Lichen striatus 
Lymphoma
Pernio
CTCL
Bugbite
87
Q

Merkel cell stains with what CD marker

A

CD20 in a perinuclear dot pattern

88
Q

Follicular mucinosis is positive for all of the following except:
CD3, CD4, CD5, CD6, CD7, CD8, CD9, CD10

A

Follicular mucinosis is negative for CD10

89
Q

What is the most specific stain for Langerhans cells??

A

CD207 (Langerin), stains Birbeck granules

90
Q

Monocytes/Macrophages stain positive for what?

A

CD68 & HAM56

91
Q

What is LCH negative for?

A

Factor VIIIa(dendritic cells), & CD68, and HAM56 (macrophages)

92
Q

Pustulosis-ovoid bodies

A

Granular cell tumor

93
Q

Who has a granular layer and who does not?

Pilar cyst vs epidermal inclusion cyst

A

EIC - granular layer

Pilar cyst - no granular layer

94
Q

Name some palisaded granuloma diseases

A

NLD, GA, some venereal diseases

95
Q

Giant cells seen in the septae of erythema nodosum

A

Miescher’s granulomas

96
Q

Miescher’s granulomas

A

Giant cells/granulomas seen in the septae of E nodosum

97
Q

What stain is more specific for calcium than Von Kossa?

A

Alizarin red. *stains calcium red-orange

98
Q

Most common stain used for calcium

A

Von Kossa

99
Q

Name the three stains that stain the pink inclusions of infantile digital fibromatosis

A

Masson trichromatic
Movats pentachrome
PTAH (phosphotungistic acid hemotoxylin)

100
Q

What is another name for the HHV-8 stain to test for Kaposis?

A

LANA-1

101
Q

LANA-1

A

Another name for the HHV-8 stain that they use to stain Kaposis sarcoma

DERMATOLOGY Premade cards (15 decks)

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