Dermatology Module 1A Flashcards
Alopecia is considered what type of disease?
Autoimmune disease
What is alopecia areata?
Patchy alopecia
What is alopecia totalis?
Face alopecia (hair loss)
What is alopecia universalis?
Hair loss over the entire body
What is the most common cause of permanent hair loss?
Androgenic alopecia (AGA) or male-pattern baldness
Androgenic alopecia has a polygenic inheritance pattern which means what?
Can be inherited from both parents
What are 2 important factors a clinician should consider in evaluation of alopecia?
Whether it’s scarring or non-scarring alopecia
And
Whether hair loss is in a small, well-circumscribed area (alopecia areata or trichotillomania) or generalized AGA
Scarring alopecia (cicatricial alopecia) causes what type of hair loss ?
Permanent hair loss and is not reversible
Non-scarring alopecia (noncicatricial alopecia) can be what?
Either temporary or permanent
Drugs that can cause hair loss include what classes? List some
Hormones
Anticonvulsants
Anticoagulants
Oral contraceptives
beta blockers
Antimetabolites
Antithyroid drugs
Excessive amount of vitamin A or topical Retin-A
What two things are helpful in the diagnosis of tinea capitis (ringworm)?
Potassium hydroxide and wood’s
light examination
What is trichotillomania?
Compulsive hair pulling
Telogen effluvium is caused by what?
Excessive shedding of scalp hair that results from an increase number of hair follicles entering the resting stage – can be caused by fever and certain drugs.
Can be caused by stress, pregnancy, and or childbirth, extreme weight loss, and general anesthesia
Alopecia areata is associated with what autoimmune endocrinopathies?
Hashimoto’s thyroid is, Addison disease, and pernicious anemia
Causes of scarring (cicatricial) alopecia can include what?
Trauma, which is physical or chemical, severe bacterial or fungal infections of the scalp, scleroderma, discoid lupus erythematosus, lichen planopilaris, and excessive radiation
A biopsy says useful in diagnosing, scarring alopecia, the specimens must be obtained from where?
Specimens must be obtained from the active border, rather than from the scarred central zone
Hair shedding is seen rapidly in a matter of days after stopping what medication?
Minoxidil (Rogaine)
Hair shedding is some more gradual over several months with what medication?
Finasteride ( Propecia )
What are the treatment options for extensive hair loss? ( greater than 50%)
Oral corticosteroids, topical, immuno, therapy, and immunomodulators
Finasteride is used in what type of population?
It is only approved for men only by the FDA
Why shouldn’t finasteride be used in women of reproductive age?
It can cause abnormalities of the external genitalia of male fetuses
What is the mechanism of action of finasteride?
Blocks effects of five alpha reductase and reduces the total amount of testosterone in the body
Finasteride is metabolized by what?
The liver
Minoxidil is for what population?
For men and women, and is available over the counter
What are the adverse effects of minoxidil?
Irritation, itching, trainers, scaling, and redness to the scalp. Can cause contact dermatitis
The larger the size of the Melanosomes has what effect of the skin color
The darker, the skin color
How is vitiligo described?
It is the total loss of skin, color and patchy areas of the body, recognize clinically as white vacuoles or patches that are usually located on the sun exposed areas
What is the theory for vitiligo being an autoimmune disorder?
The body produces antibodies against its own melanocytes.
Vitiligo occurs more often to individuals with autoimmune diseases, such as hyperthyroidism, adrenal insufficiency, alopecia, areata, and pernicious anemia
What are some lab tests you would do for vitiligo?
CBC, peripheral smear, thyroid function, studies, anti-nuclear antibodies, test, and an eye examination to rule out uveitis
What are some current treatments for vitiligo?
Topical corticosteroids, light therapy, UVA therapy, UVB, light, depigmentation with top of creams and surgical approach is including skin grafts
What is chloasma?
It is referred as a mask of pregnancy, it is a hyper pigmentation condition that is caused by increase levels of estrogen, progesterone, and melanocyte, stimulating hormone during pregnancy.
?
What are common areas affected in pts with chloasma?
Areas include the face, jaw line, nipples, genitals, and the linea Negra extending from the umbilicus to the pubis
Diagnosis of cold asthma, and the extent of epidermal/dermal involvement is determined by what?
Performing a wood’s lamp examination to visualize excess melanin in the epidermidis
Treatment of chloasma includes what?
Includes retinoic acid, hydroquinone, cream, tretinoin, and corticosteroids with Hydroquinone, azelaic acid or Kojic acid creams, glycolic acid peels, micro, dermabrasion, galvanic, or ultrasound facials, and various laser and intense pulsed light photo rejuvenation treatment
What is important to know about hydroquinone and treating chloasma/melasma?
It is not recommended for women who are pregnant or planning to become pregnant. Patient should be referred to obstetrician for management.
What should be done to rule out allergy to any bleaching agent?
A 24 hour skin touch test should be done to rule out any allergy to any bleaching agent
How often should a bleaching agent to be applied to treat melasma?
The cream can be applied twice a day for two months
What is the first line treatment for melasma?
Prescription, bleaching cream, such as hydroquinison and strict sun avoidance
What are some drugs that can cause diffuse hyper pigmentation?
Zidovudine, cyclophosphamide.
Skin discoloration has been reported in patients who have been taking amiodarone, chlorpromazine, and certain antimalarial drugs
What are laboratory findings of Addison’s disease?
Elevated is there an potassium and calcium, lo, serum, sodium, anemia, and elevated ACTH level
A variegated color or very dark color on one solitary nail should arouse suspicion for what?
Acral Melanoma
What does the mnemonic ABC DE stand for in regards to detecting skin cancer?
A is asymmetry
B is border irregularity
C is color variegation
D is diameter (greater than 6mm)
E is elevation or evolving
If Nighttime Pruritus is a symptom, the clinician should have high suspicion of what?
Scabies
If a pruritic rash does not respond to symptomatic treatment, a work up for systemic disease is in order, what labs?
CBC with differential, ESR, fasting, blood sugar, liver and renal function, test, thyroid, panel, and viral hepatitis panel
What is xerosis?
Dry skin
What’s important to know about the classic rash of mammary Paget’s disease?
Has a rash that looks like eczematous dermatitis of the nipple and areola.
Early in it’s disease, the pt can be asymptomatic except for a rash.
Usually on the nipple or areola, oval shaped with red scaling plaque and sharp margins
Patients with a mammary Paget’s disease should be referred to whom?
A breast specialist
If a rash on the nipple or areola region last longer than 2 weeks and does not resolve with topical steroids, refer to breast specialist
Toxic shock syndrome is an acute Illness caused by what?
Toxin producing S.aureus
What are symptoms of toxic shock syndrome?
Sudden onset of fever, vomiting, tingling sensation of hands and feet, myalgia, headache, diarrhea, weakness
What immunoglobulin is urticaria associated with?
IgE
Topical corticosteroids should not be applied to rashes that are suspected to be or what etiology?
Viral
Because it can make it worse
What meds should be avoided in pts who have urticaria?
Aspirin, ace inhibitors, and NSAIDs
The classic prescription antihistamine used for pruritus and urticaria is what?
Hydroxyzine 50 mg to reduce risk to day time drowsiness/sedation
Human scabies is caused by the itch mite ?
Sarcoptes scabiei var. hominis
What is the earliest physical sign of scabies?
1 to 2 mm red papilla located in areas of the body that are most attractive to mites
Where are the highest yield of mites located?
On the finger webs, penis or wrists
What diagnostic test should be done to test for scabies?
The burrow ink test
Explain the burrow ink test
The burrow ink test is performed by rubbing a blue/green marker/felt tip over the suspected burrow and wiping off with alcohol then use a drop of mineral oil and use 15 scalpel blade. The scrapings should be placed in a slide with a drop of oil then sealed to examine under microscope
Management of scabies includes what?
The patient, his/her close contacts and surrounding environment
What is the first line treatment for scabies?
Permethrin to treat scabies
Antihistamines and topical steroids for pruritus
Lindane has what effect on pts for scabies and not commonly used because?
It’s the most toxic, can cause seizures, irritability. Not good for pregnancy
When is follow up for uncomplicated scabies?
1 week after initial treatment
May need to repeat scabicide treatment
Pthirus pubis is called what kind of louse?
Pubis louse
Infects pubis primarily
Pediculus human capitis is called what louse?
The head louse
Affects scalp
Pediculus human corporis is what louse?
The body or clothing louse
Children ages 3 to 12 are affected most commonly by what louse?
The head louse
Which lice are associated with disease transmission?
Body lice
What is the earliest sign of lice infestation?
Small 2-3mm, red erytbematous macules or papilla that may be pruritic
children with Pediculosis pubis in their eyelashes or hair should alert the clinician of what ?
Possible sexual abuse
Eyelash infestation can be treated by what?
Applying petroleum jelly to the eyelid margins twice daily for 10 days
What is the first line treatment for pediculosis?
use permethrin 1% lotion or 5% cream (Nix)
Moniliasis is also known as what?
Candidiasis
A higher incidence of thrashes seen among which two types of patients?
AIDS patients and infants
In women with aids one of the earliest and most frequent opportunistic infections is what?
Vaginal candidiasis
Patients with oral candidiasis or thrush will complain of what?
Hey severe sore throat, painter, difficulty is noted during swallowing, especially with acidic foods
Patients with vaginal candidiasis or complaining of what typically?
Burning, itching, and irritation, either and/or the vagina. Burning may be noted during intercourse or urination.
Patients with vaginal candidiasis, has what kind of discharge?
Vaginal discharge is reported as white in color, with a cottage cheese, or thick texture appearance
What is balanitis?
It is the yeast infection of the glans penis
What is the typical complaint in men who have balanitis?
Sexually active adult male who complains of reddish rash and itching of the glans penis.
Sometimes has burning after intercourse but none with urination.
Some will report having sex with a female partner who is being treated for a yeast infection
What is intertriginous candidiasis?
It is a red itchy rash that occasionally “weeps” and is moist, sometimes accompanied by burning.
What are some locations for intertriginous candidiasis?
The groin, the perianal area, and traditional spaces are both hands and feet, the inframammary area
Usually in obese adults
What is candidal paronychia?
Fungal infection of fingertip
What is the classic description of candidal paronychia?
Extremely painful fingertip that is red, hot, and swollen. History of frequent water immersion of the hand.
What is subungal candida?
One of several discolored Yellow fingernails for several weeks to months
No pain or itching is associated
Excessive contact with dish water, bartending.
What is the cardinal symptom of candidiasis?
Pruritus and sometimes burning
What is a cardinal sign of cutaneous candidiasis infection ?
Bright red rash with macules or satellite lesions see on borders
What are the objective signs of balanitis?
Glans penis has small red and eroded patches that are tender to touch
Can also be small white round lesions with a red base on the glans
What does intertriginous candidiasis look like?
Found in areas of skin maceration (skin rubbing against skin) or increased heat and moisture can become easily colonized
Think axilla, groin, perianal, interdigital areas