Dermatology Flashcards
What is a macule?
Flat, non-palpable change in skin colour, <0.5cm diameter
What is a patch?
Flat, non-palpable change in skin colour, >0.5cm diameter
What is a vesicle?
Fluid within upper layers of skin, <0.5cm diameter
What is a blister?
Fluid within upper layers of skin, >0.5cm diameter
What is a bulla?
Large fluid-filled lesion below epidermis, >10cm diameter
What is a pustule?
Visible collection of pus in subcutis
What is a nodule?
Mass or lump >0.5cm diameter
What is a callus?
Hyperplastic epidermis, often found on the soles,
palms + other areas of excessive use
What is a plaque?
Raised area >2cm diameter
What is a wheal?
Dermal oedema
What is a fissure?
Linear crack
What is an ulcer?
Full thickness skin loss
What is an excoriation?
Scratch mark
What is lichenification?
Thickening of epidermis with exaggerated skin marking usually due to repeated scratching
What are telangiectasia?
Easily visible superficial blood vessels
What is purpura?
Rash caused by blood in skin
What is petechia?
Micro-haemorrhage, 1-2mm diameter
What are some examples of hypopigmented or depigmented lesions?
Vitiligo
Pityriasis versicolor
Pityriasis alba
What are some examples of hyperpigmented lesions?
Lentigos Café-au-lait spots Melasma (chloasma) Melanocytic naevi Seborrhoeic keratoses Systemic diseases: Addison’s, haemochromatosis
What are some examples of ring shaped lesions?
BCC
Tinea (ringworm)
Granuloma annulare
Erythema multiforme
What are some examples of round/discoid lesions?
Bowen’s disease Discoid eczema Psoriasis Pityriasis rosea Erythema migrans Impetigo
What are some examples of linear lesions?
Kobner phenomenon: lesions related to skin injury
Dermatitis artefacta: lesions induced by pt
Herpes zoster
Scabies burrows
What dermatological conditions cause itchy lesions?
Scabies, urticaria, atopic eczema, dermatitis herpetiformis, lichen planus
What systemic diseases are associated with itchy lesions?
Iron def., lymphoma, hypo/hyperthyroidism, liver disease, CKD, polycythaemia, drugs (statins, ACEi, opiates)
How should vitiligo be managed?
Sun protection, cosmetic camo, topical steroids may induce repigmentation, phototherapy
What is pityriasis versicolor?
Superficial slightly scaly yeast infection
Appears hypopigmented on darker skin
What is pityriasis alba?
Post-eczema hypopigmentation, often on child’s face
What are lentigos?
Brown macules/patches that persist in winter, unlike freckles
Describe the appearance of seborrhoeic keratoses:
Benign greasy-brown warty lesions usually on back,
chest and face
Stuck on appearance
What are actinic (solar) keratoses?
Pre-malignant crumbly yellow-white scaly crusts on sun-exposed skin
What are some management options for actinic keratoses?
Observation
Topical 5-FU, imiquimod or diclofenac
Cryotherapy, photodynamic therapy
Surgical excision and curettage
What is Bowen’s disease?
Well-defined slowly enlarging red scaly plaque with flat edge
3-5% progress to SCC
What are some management options for Bowen’s disease?
Cryo, topical 5-FU or imiquimod,
photodynamic, curettage, excision
What is keratoacanthoma?
Smooth dome-shaped papule, rapidly grows to become a crater centrally
What is the management for keratoacanthoma?
Urgent excision
Describe the appearance of squamous cell carcinoma:
Persistently ulcerated or crusted firm irregular lesion often on sun-exposed sites
What factors increase the risk of metastasis in squamous cell carcinoma?
If on lip, ear or non-sun exposed site
>2cm
Poor differentiation
Immunosuppression
What is the management for squamous cell carcinoma?
Local complete excision with 4-6mm margin
Describe the appearance of nodular basal cell carcinoma:
Pearly nodule with rolled telangiectatic edge on face or sun-exposed site
Describe the appearance of superficial basal cell carcinoma:
Red, scaly plaques with raised smooth edge, often on trunk or shoulders
How should basal cell carcinoma be managed?
Excision
Can use cryo, curettage, RT, photodynamic, topical if superficial at low risk site
What cancers may metastasise to the skin?
Breast, stomach + colon, lung, genitourinary
What is leukoplakia? Who is it more common in?
Premalignant condition, white hard spots on mucous membrane of mouth
More common in smokers
What is mycosis fungoides?
Cutaneous T-cell lymphoma
Well-defined itchy red scaly plaques progressing to red-brown infiltrated plaques and ulcerating tumours
What is Fitzpatrick skin type I?
Pale white skin, blonde/red hair
Always burns, does not tan
What is Fitzpatrick skin type II?
Fair skin, blue eyes
Burns easily, tans poorly
What is Fitzpatrick skin type III?
Darker white skin
Tans after initial burn
What is Fitzpatrick skin type IV?
Light brown skin
Burns minimally, tans easily
What is Fitzpatrick skin type V?
Brown skin
Rarely burns, tans darkly easily
What is Fitzpatrick skin type VI?
Dark brown or black skin
Never burns, always tans darkly
What are some risk factors for malignant melanoma?
UV exposure, sunburn, fair complexion, >50 melanocytic or dysplastic naevi, FH, previous melanoma, age
What are some signs of malignant melanoma (ABCDEF)?
Asymmetry in outline of lesion Border irregularity Colour variation Diameter >6mm Evolution (size, elevation, colour) Funny looking mole, different from others/mole signature
What are the types of malignant melanoma?
Superficial spreading (70%)
Nodular (15%)
Acral lentiginous (10%)
Lentigo maligna melanoma (5%)
How should malignant melanoma be managed?
Excision biopsy with 2mm margin allowing for histological diagnosis and Breslow thickness
If MM confirmed, wider excision (up to 3cm) to
ensure complete removal and may do SNLB
How should metastatic melanoma be managed?
Palliation: chemo, biological, novel targeting therapy and ipilimumab
What is psoriasis?
Chronic inflammatory skin condition characterised by scaly erythematous plaques, typically relapsing remitting course
What are some triggers for psoriasis?
Stress, infections, skin trauma (Kobner), drugs (lithium, NSAIDs, beta blockers), withdrawal of systemic steroids
What are the types of psoriasis?
Chronic plaque Flexural Guttate Pustular Generalised
Describe chronic plaque psoriasis:
Symmetrical well-defined red plaques with silvery scale on extensor aspects, scalp and sacrum
Describe guttate psoriasis:
Large numbers of small plaques <1cm (teardrop) over trunk and limbs, seen in young (esp. after acute strep infection), lasting 3-4m
What nail changes are associated with psoriaisis?
Pitting, onycholysis (separation from nail bed),
thickening, subungal hyperkeratosis
How should psoriatic arthropathy treated?
NSAIDs, DMARDs, anti-TNF
What are the management options for psoriasis?
Emollients
Topical corticosteroid and topical vit D
Phototherapy or systemic therapy if not controlled or if >10% body area affected
What are the side effects of phototherapy?
Increased risk of SCC, sunburn, dry skin, folliculitis, cold sores, polymorphic light eruption
What non-biologic oral drugs may be used in the management of psoriasis?
Methotrexate
Ciclosporin
Acitretin
Dimethyl fumarate and apremilast
What biologics may be used in the management of psoriasis and what is the MoA?
Inhibit T cell activation and function or neutralise cytokines
Infliximab, adalimumab, etanercept (anti-TNF), ustekinumab (interleukin inhibitor)