Dermatology Flashcards
What is included in the atopic disease triad?
- Eczema
- Allergic rhinitis
- Asthma
Usually starts in childhood
Altered immune reaction in genetically susceptible people when exposed to certain triggers - causes an increase in IgE production
Atopic dermatitis (Eczema)
Triggers for Atopic dermatitis (Eczema)
Heat
Perspiration
Allergens
Contact irritants (wool, nickel, food)
Hallmark of atopic dermatitis (eczema)
pruritus!
Erythematous, ill-defined blisters/papules/plaques that later dries, crusts over and scales
Atopic dermatitis (eczema)
Atopic dermatitis (eczema) is most commonly found:
Flexor Creases
Antecubital fold and popliteal folds
Special characteristic of atopic dermatitis (eczema)
Dermatographism - localized development of hives when the skin is stroked
Sharply defined discoid/coin shaped lesions found on the dorsum of the hands, feet, and extensor surfaces (knees, elbows)
Nummular Eczema
Atopic dermatitis
Management of atopic dermatitis (eczema)
- Topical corticosteroids, antihistamines for itching
2. Topical calcineurin inhibitors (Tacrolimus, Pimecrolimus) are alternatives for steroids
Seborrheic dermatitis may be due to a hypersensitivity to:
Malassezia furfur
Seborrheic dermatitis is most commonly seen in:
Adult men
Seborrheic dermatitis occurs most common in areas of:
High sebaceous gland over secretion - scalp, face, eyebrows, body folds
Erythematous plaques with fine white scales seen on infants heads
Cradle Cap - Seborrheic Dermatitis
Erythematous plaques with fine white scales seen on the scalp, eyelids, beard/mustache, etc.
Seborrheic dermatitis
Management of seborrheic dermatitis
Topical: selenium sulfide, sodium sulfacetamide, ketoconazole (shampoo or cream)
Systemic: oral antifungals - itraconazole, fluconazole, ketoconazole, terbinafine
Triggers for dyshidrosis
Sweating
Emotional stress
Warm and humid weather
Metals (ex. nickel)
Pruritic “tapioca-like” tense vesicles on the soles, palms, and fingers
Dyshidrosis
Management of dyshidrosis
Topical steroids - ointment preferred
Cold compresses
Skin thickening in pts with eczema secondary to repetitive rubbing/scratching
Lichen simplex chronicus
Scaly, well-demarcated, rough hyperkeratotic plaques with exaggerated skin lines
Lichen simplex chronicus
Management of lichen simplex chronicus
Avoid scratching!
Topical steroids (high strength)
Antihistamines
Occlusive dressings
Has an increased incidence with Hepatitis C
Lichen planus
The 5 P’s of lichen Planus
Purple, polygonal, planar, pruritic papules
Lichen planus most commonly seen on:
Flexor surfaces, skin, mouth, scalp, genitals, nails and mucous membranes
Koebner’s Phenomenon
New lesions at site of trauma
Seen in psoriasis and lichen planus
Fine white lines on the skin lesions or on the oral mucosa - nail dystrophy
Wickham Striae
Seen in lichen planus
Management of lichen planus
Topical corticosteroids
Antihistamines for pruritus
Rash will usually spontaneously resolve in 8-12 mo
Urticaria and angioedema are _____ mediated and usually occur immediately after offending drug/trigger is taken
IgE
Erythema multiforme is a __________ reaction that is usually delayed and cell mediated
Morbilliform
Most common type of drug reaction/skin eruption
Exanthematous / Morbilliform Rash
Generalized distribution of “bright-red” macules and papules that coalesce to form plaques - typically begins 2-14 days after medication initiation
Drug eruption
Exanthematous/Morbilliform Rash
2nd most common type of drug eruption
Urticaria
3rd most common type of drug eruption
Erythema multiforme
Most common type of drug eruption
Exanthematous/morbilliform
Most common offending drugs with urticaria
Antibiotics and NSAIDs
Management of drug induced exanthematous/morbilliform rash
Oral antihistamines
Management of drug induced urticaria / angioedema
Systemic corticosteroids, antihistamines
Management of drug induced erythema multiforme
Symptomatic therapy
Topical steroids, oral antihistamines
Associated with Human Herpes Virus 7
Pityriasis Rosea
This rash can mimic syphilis, so an RPR should be ordered if the pt is sexually active
Pityriasis Rosea
Solitary salmon-colored macule on the trunk, followed by general exanthem 1-2 weeks later
Herald Patch
Pityriasis Rosea
Very pruritic salmon-colored papules with collarette scaling along cleavage lines in a christmas tree pattern
Pityriasis Rosea
Management for pityriasis rosea
None needed
PO antihistamines, topical corticosteroids as needed
Can use UVB phototherapy if severe and started early
Keratin hyperplasia due to T cell activation leads to greater epidermal thickness and increased epidermis turnover
Psoriasis
Raised, dark-red plaques/papules seen with thick silver/white scales
Psoriasis
Plaque Psoriasis is most common seen on the:
Extensor surfaces
Elbows, knees, scalp, nape of neck
25% of plaque psoriasis also have:
Nail pitting
Yellow-brown discoloration until the nail (oil spot)
Punctate bleeding with removal of plaque/scale
Auspitz sign
Seen with psoriasis and actinic keratosis
Deep, yellow non-infected pustules that evolve into red macules on palms/soles
Pustular psoriasis
Erythematous rash that lacks scales, seen in body folds (groin, gluteal fold, axilla)
Inverse psoriasis
Inflammatory arthritis that includes joint stiffness > 30 minutes relieved with activity. May also have “sausage digits”
Psoriatic arthritis
Radiograph deformity seen with psoriatic arthritis
Pencil in cup deformity
Management for psoriasis
Topical steroids first line
Moderate-severe: phototherapy
Systemic treatment: Methotrexate
Most common cause of erythema multiforme
Secondary to herpes simplex infection
Multiple target-like lesions that spares the mucosa
Erythema Multiforme Minor
Multiple target-like lesions that includes mucosal involvement
Erythema Multiforme Major
Treatment of erythema multiforme
Typically resolves after 2 weeks
Can give topical steroids and antihistamines
Most common medications causing SJS and TEN
Allopurinol Sulfonamides Lamotrigine NSAIDs Anticonvulsants
SJS affects _______% of body surface area
< 10%
TEN affects _______% of body surface area
> 30%
Prodrome of fever, malaise, myalgias followed by lesions on face and trunk. Bullous and vesicle formation begins days after
SJS/TEN
Gentle pressure to the skin causes sloughing
Nikolsky Sign
Seen in SJS/TEN
Main cause of death with SJS/TEN
Sepsis and shock secondary to infection
Treatment for SJS/TEN
Admit to hospital, preferably to burn unit
Supportive care is mainstay
Chronic widespread autoimmune blistering skin disease primarily of the ELDERLY
Bullous pemphigoid
Bullous pemphigoid will have ________ of Nikolsky sign
Absence
Bullous pemphigoid is caused by an ______ autoimmune attack on the epithelial basement membrane
Type II HSN
IgG
Management of bullous pemphigoid
Systemic corticosteroids
Antihistamines
Azathioprine (immunosuppressant)
4 main pathophysiologic factors for acne vulgaris:
- Increased sebum production
- Clogged sebaceous glands
- P. acne overgrowth
- Inflammatory response
Small, non inflammatory bumps from clogged pores
Comedones
Acne vulgaris
Treatment for mild acne
Topical retinoids
Benzoyl peroxide
Topical abx (Clindamycin)
OCPs
Treatment of rmoderate acne
Oral abx (Doxy, Minocycline, Erythromycin, Clindamycin)
Treatment of severe (nodular/cystic) acne
Isotretinoin
S/E of isotretinoin
Highly teratogenic
Hepatitis, increased triglycerides/cholesterol, psych side effects
What must be done before prescribing isotretinoin?
Highly teratogenic
Obtain at least 2 pregnancy tests prior to initiation and monthly
Must be on 2 forms of contraception
Symptoms due to increased capillary permeability and increased vasomotor instability with lesion formation
Rosacea
Triggers for Rosacea
EtOH Hot/cold temperature Hot drinks Hot baths Spicy foods
Acne-like rash, erythema, facial flushing, telangiectasia
Rosacea
Absence of comedones distinguishes it from acne
Rosaceae
Treatment for rosacea
Metronidazole first line
Topical abx
Can do oral abx if severe
Lifestyle modifications for rosacea
Sunscreen, avoid toners, camphor and triggers
Most commonly seen in fair-skinned elderly with prolonged sun exposure
Actinic keratosis
Seborrheic keratosis
Premalignant condition to squamous cell carcinoma
Actinic keratosis
Most common premalignant skin condition
Actinic keratosis
Dry, rough, scaly “sandpaper” skin lesion or erythematous, hyperkaratotic
Actinic keratosis
May present with a projection (horn) on the skin
Actinic keratosis
Diagnosis of actinic keratosis
Punch or shave biopsy
Management of actinic keratosis
Observation, surgical
Topical 5-fluorouracil, imiquimod
Most common benign skin tumor
Seborrheic keratosis
Small papule/plaque velvety warty lesions with a greasy/stuck on appearance
Seborrheic keratosis
Intense itching, especially in the occipital area, papular urticaria may been seen
Lice
White oval-shaped egg capsules at the base of the hair shafts
Nits
Lice
Management of lice
Permethrin topical drug of choice
Safe in children > 2 y/o
If lice in hair: permethrin shampoo (leave on 10 min)
If pubis/body: permethrin lotion at least 8-10 hours
Second line management of lice and S/E
Lindane
Neurotoxic - headaches, seizures
Do not use after showering