Dermatology Flashcards
What is porphyria cutanea tarda?
Deficiency in the haem-synthetic enzyme URO-D (uroporphyrinogen decarboxylase) in the liver.
This leads to porphyrins which are photoactive (i.e. light activated) and cause oxidative damage to the skin.
What is the most common cause of Tinea capitis? Which population is most affected by this? What is the typical clinical feature?
Trichophyton tonsurans (fungus) causing a dermatophyte infection in the scalp.
Occurs mostly in populations of lower socioeconomic status.
Typical feature: scaly circular plaque (ring worm)
Patient has a rash, biopsy reveals septal panniculitis. Diagnosis?
Erythema nodosum
Patient has a rash, biopsy reveals intradermal clefting with eosinophils, what might the diagnosis be?
Pemphigus
Patient has a rash, biopsy reveals subepidermal bulla with eosinophils, what might the diagnosis be?
Bullous pemphigoid
What is Lichen Planus?
How is it treated?
Mucocutaneous disorder that affects middle-aged adults with unknown cause, may be drug-induced and associated with Hep C.
May implicate skin, nails or mucous membranes. Cutaneous lichen planus is a pruritic rash with papules +/or plaques with an overlying ‘white lace-like’ pattern (Wickam’s Striae)
Treatment: high potency topical corticosteroids.