Dermatology Flashcards
Acne non-pharmacological management
- Avoid heavy cleansing
- Avoid cheap soaps/washes
- Avoid excessive scrubbing/exfoliating
(All cause MORe irrigation to epidermis, blocks sebaceous glands)
- Use non-comdeogenic and non-acnegenic creams, cosmetics and sunscreen instead
- Do not squeeze/pick pimples
- Balanced, healthy diet
- Minimise exposure to hot/humid environments (steam, kitchens, spas)
- Smoking cessation
Acne pathophysiology - 4 steps
- Abnormal increased proliferation of follicular keratinocytes –> follicular plug
- Increased sebum production from sebaceous follicles
- Proliferation of microorganisms within sebum
- Inflammation
Acne mild treatment (3 steps)
- OTC products - benzoyl peroxide 5%
- –> Topical retinoid (e.g adapelene 0.1% gel or cream, tretinoin 0.025% cream)
Apply 2nd nightly for 2/52 then nightly
Review after 6/52
(TERATOGENIC!!!) - –> Topical combination
comedonal - Benzoyl peroxide+adapalene 2.5%+0.1% gel, once daily
inflammatory - benzoyl peroxide+clindamycin 5%+1% gel, once daily
R/v after 6/52
Acne moderate treatment (men, if pregnant, women)
- Doxycycline 50mg-100mg daily 6/52 then r/v
- Minocycline 50mg-100mg daily 6/52 then r/v
If pregnant
1. Erythromycin 250-500mg BD 6/52 then r/v
Women
1. COCP; ethinylestradiol+cyproterone
Acne severe treatment (1) + main risk + side effects (6)
Isotretinoin (refer Derm)
Main risk teratogenicity Cat X - recommend double contraception
A/e’s
- Dry skin
- Epistaxis
- Photosensitivty
- Myalgias
- headaches
- LFT derangement
Features on history to assess for skin cancer risk assessment
- Ethnic background, skin phototype (Fitzpatrick skin type I-II high risk), red hair
- Immunosuppression
- Recent change in lesions
- Symptomatic lesions (bleeding/pruritis?)
- PHx of skin Cancer/removal of suspicious lesion
- Tendency to sunburn
- Occupational risk
- Time spent outside/outdoors
>100 naevi or >10 dysplastic naevi
Tinea cruris management
Topical antifungal (terbinafine 1% gel) once or twice daily for 7-14 days
+/- hydrocortisone cream
Impetigo Rx in endemic settings
Bactrim 160/800mg BD 3 days
(IM Benzathine Benpen also 1st line, 1.2 million units)
Pyoderma gangrenosum associated conditions (3)
- IBD
- Rheumatoid arthritis
- Myeloid blood dyscrasias (e.g leukaemia)
Melasma risk factors
- UV exposure
- Hormones (oestrogen/prog) - e.g during pregnancy/COCP/MHT
- Soaps/cosmetics
- Heat exposure
- Can be a/w thyroid disease
Melasma Rx
- Kligman’s formula (gold standard) - combo of hydroquinone/tretinoin/dexamethasone, BD for 3 weeks
- Azelaic acid 5-20% BD
- Tranexamic acid 2-5% BD
- Hydroquinone cream 2-5 % daily
- High fever 3-5 days (+/- URTI sx, lymphadenopathy) –> rash appears as fever subsides
- Rash starts on trunk then spreads to neck, limbs and face
Roseola infantum (HHV6-7)
When can Hand Foot Mouth disease kids go back to school
Blisters stop being infective once dried (but can continue shedding in stools for a month)
Plaque psoriasis management options - broad (3)
- Tar (6% LPC/3% salicylic acid cream) - generally 4 weeks
- Corticosteroids - generally methylpred for 2-6 weeks
- Calcipotriol - nails/palsm
Psoriatic nail changes (5)
- Oil spots
- Horizontal ridges
- -Onycholysis*
- -Subungal hyperkeratosis*
- -Pitting - last 3 overlap with onychomycosis*
Onychomycosis treatment
Terbinafine 250mg daily 12 weeks toenails, 6 weeks fingernais
2nd-line alts - fluconazole, itraconazole
Vitiligo history (risk factors) (4)
PHx/FHx autoimmune disease - thyroid, coeliac, alopecia areata
-STRONG a/w thyroid disease - consider testing thyroid Ab
FHx vitiligo
Hx melanoma
Emotional stress
Impetigo non-endemic Rx
- Localised
- Multiple sores
- Pen allergy delayed
- Pen allergy immediate
- Mupirocin 2% ointment TDS 5/7
- Fluclo/diclox 500mg QID 7/7
- Cefalexin 500mg QID 7/7
- Bactrim 160/800 BD 3 days