Cardiology Flashcards
Acute chest pain DDx (7)
ACS Aortic dissection PE Pneumothorax Coronary artery spasm Oesophageal rupture/spasm Pericarditis
Acute Cardiac Chest pain - immediate management (meds + doses)
O2 if Sats <94% Aspirin 300mg PO Stat GTN spray (400-800mcg s/l, or tab 300-600 mcg s/l) every 5 mins, up to 3 doses (IF HAEMODYNAMICALLY STABLE) 2x large bore IV access IV Morphine 2.5-5mg, every 5-10 minutes
Already high CVS risk groups (7)
- Diabetes + age .60
- Diabetes w/ microalbuminuria (ACR >2.5)
- Mod CKD (eGFR <45)
- Familial hypercholesterolaemia
- TChol >7.5
- BP >180/>110
- ATSI age >74 y.o
Other 2ndary causes of HTN (5)
- Primary aldosteronism (Conn’s syndrome)
- Cushing’s disease
- Phaeochromocytoma
- Renovascular disease
- OSA
Treatment failure considerations ○ Non-adherence ○ Undiagnosed secondary conditions ○ Other meds causing hypertensive effects ○ OSA ○ Use of eTOH/illicit drugs ○ High salt intake ○ White coat ○ Volume overload (esp. w/ CKD)
AAA risk factors (6)
- Peripheral vascular disease
- Smoking
- HTN
- COPD
- Marfans
- First-degree relative
Metabolic syndrome diagnostic criteria (5)
- Elevated waist circumference
- Elevated triglyceride levels >1.7
- Reduced HDL <1.0 (<1.3 in women)
- Elevated BP >130/85
- Elevated fasting glucose >5.5
Other causes of elevated troponin apart from ACS (9)
- Cardiac surgery
- Post-ablation or PPM insertion
- HOCM
- Tachyarrhythmias
- Infiltrative disease (sarcoid, amyloid)
- Myocarditis
- PE
- Renal failure
- Rhabdo
Who is coronary calcium scoring suitable for?
Low -intermediate CVS risk people who are asymptomatic
Heart failure definitions
HFrEF = symptoms/signs and LVEF <50%
HFpEF = symptoms/signs and LVEF >50% and
–objective structural heart disease (LV hypertrophy, atrial enlargement)
–diastolic dysfunction
Heart failure specific symptoms (4) and signs (4)
Symptoms: -Dyspnoea -Orthopnoea -PND -Fatigue Signs -Elevated JVP -Hepatojugular reflex -3rd heart sound -Laterally displaced apex beat
HFpEF Rx (2)
-Diuretics + HTN management (MRA, ACEi/ARB preferred)
heart failure Acute decompensation causes (9)
- AMI
- Hypoxia
- Arrhythmia (AF/VE’s)
- Pericardial tamponade
- Infections
- Anaemia
- Thyroid disease
- Acute renal failure
- New meds
HFrEF medical management algorithm
- Congested vs. euvolaemic
- How often to uptitrate meds
- When to repeat TTE
- Other options
- Uptitrate meds every 2-4 weeks
- Repeat TTE in 3-6 months
- Change ACEi/ARB to ARNI if persistent HFrEF <40%
- Consider ivabradine or device therapy if LVEF <35% and sinus rhythm >70bpm
Approach to managing Heart Failure comorbidities:
- HTN
- Coronary artery disease
- AF
- Hyponatraemia
- COPD
- Arthritis
-HTN
• Avoid diltiazem/verapamil/moxonidine in HFrEF
• HFpEF –> MRA +/- ACEi/ARB
-Coronary artery disease
• Ivabradine if sinus HR >70bpm and LVEF <35%
-AF
• B-blockers and digoxin preferred for rate control
-Hyponatraemia
• Restrict fluid
• Reconsider need for diuretics
-COPD
• B-blockers are safe for most w/ COPD
-Arthritis
• Avoid NSAIDs if ↓severe LVEF or hyponatraemia
AF anticoagulation doses & dose reduction criteria
Apixaban 5mg BD
–Dose reduce if 2 of, age >80, weight <60kg, Creat >133
Rivaraoxaban 20mg daily
–Dose reduce 15mg daily if CrCl 30-49 AND/OR combo w/ DAPT
Dabigatran 150mg BD
–Dose reduce to 110mg BD if age >75 OR CrCl 30-50 OR combo w/ DAPT
- Bleeding risk scores should not be used to avoid anticoagulation in pts w/ AF - net benefit always favours stroke prevention > major bleeding
- NOACs preferred to warfarin (even reasonable to change to NOAC from warfarin)
- If antiplatelet agents indicated (e.g post-ACS or stent), only use clopi+aspirin for up to 12 mths
- If Crl <30, use warfarin
AF Risk Factors (8)
-Heart failure
-HTN
-Valvular heart disease
-T2DM
-Obesity
-OSA
-Alcoholism
-Hyperthyroidism
AF risk factors for bleeding (6)
-HTN
-Labile INR
-Excess eTOH
-Anaemia
-Renal/liver impairment
-Frailty and falls
AF Rhythm control - preferred in who?
-Younger, physically active people, highly symptomatic
-Paroxysmal/early persistent
-Presence of Left Ventricular dysfunction
-No severe L) atrial enlargement
-Adequate rate control difficult
AF acute rhythm control options (3)
-Synchronised DC cardioversion (defer for 3/52 of OAC or TTE if AF >48 hours)
-Fleicainide
-Amiodarone
AF long-term rhythm control options
-If no LV dysfunction
-If LV dysfunction
-Alternative
If no LV dysfunction or CAD - flecainide 50mg BD sotalol 40mg BD
If LV dysfunction - amiodarone 200mg TDS –> wean
-Catheter ablation (continue anticoag EVEN AFTER procedure if high stroke risk)
AF long-term rate control options (4)
-Beta-blockers (atenolol 25mg daily, metoprolol 25mg BD)
-Non-DHP CCBs (Diltiazem/verapamil 180mg MR daily) - avoid if LV dysfunction
-Add digoxin to above (2nd line)
-Add amiodarone to above - 200mg daily
DVT risk factors (6)
○ PHx of DVT
○ Sudden immobility/extended travel (within four weeks)
○ Surgery/medical illness (within three months)
○ Hormonal contraception
○ Pregnancy
○ FHx of venous disease
DVT - blood tests before starting anticoagulation (4)
-FBE
-UEC/LFT
-Coags
-Beta-hcg (confirm not pregnant)
DVT anticoagulant dosing
-Rivaroxaban 15mg BD for 3/52 –> 20mg daily
-Apixaban 10mg BD for 1/52 –> 5mg BD
CrCl needs to be >30
Dabigatran & warfarin need concurrent clexane as well
Clexane if pregnant
Post-thrombotic syndrome prevention (1)
Graduated compression stockings from ankle to just below knee, 30-40mmHg
Rheumatic heart disease management aspects (7)
○ Benzathine benpen 1.2 million units IM every 4 weeks
-Notifiable conditon (WA/NT/QLD/SA/NSW)
-Education re: early treatment of strep infections to prevent recurring ARF
-Continue anticoagulation during pregnancy
-Regular specialist r/v / TTE/dental review
-Annual flu vaccine
-Consider endocarditis prophylaxis for surgeries
Endocarditis prophylaxis criteria (2)
1) Pre-existing cardiac condition (e.g prosthetic heart valve, rhuematic heart disease)
2) Type of procedure - dental, derm/MSK procedures w/ infected skin, resp/ENT, genitourinary/GI procedures
HOCM inheritance pattern?
-Clinical presentation?
-Ix? (3)
-Autosomal dominant
-Often asymptomatic, usually exertional dyspnoea. Can have abnormal ECG/systolic murmur
-ECG - large QRS voltages +/- ST segment or T wave repolarisation changes
-TTE
-Holeter monitor - assess for presence of VT
HOCM management aspects (5)
-Cease playing competitive sport (can do low-mod intensity exercise)
-Meds - bblockers/verapamil for symptomatic pts
-Septal reduction tehrapy - if severe LVOT
-ICD - if 1> RFs for sudden cardiac death
-Family screening - all 1st-deg relatives - exam, ECG, TTE
–Cascade screening for pathogenic HCM mutation
No need for prophylactic endocarditis Abx
Pericarditis management
+1 examination finding
-Aspirin 750mg-1000mg TDS for 1-2/52
OR Ibuprofen 600mg TDS for 1-2/52, then wean
PLUS colchicine 500mcg BD (if >70kg) or daily (if <70kg)
PLUS activity restriction
Pericardial friction rub on ausc @ L) lower sternal border
Routine investigations for newly diagnosed AF (6)
-FBE
-UEC
-TSH
-CMP
-TTE
-24 hour Holter
Heart failure/APO initial investigations (8)
-ECG
-CXR
-Trop
-UEC
-FBE
-TSH
-Iron studies
-Echo
Scleroderma patients - increased risk of what 3 conditions?
-Pulmonary hypertension (most commonly due to L) heart disease)
-Interstitial lung disease
-Anaemia
Scleroderma Ix (3) & Rx aspects (3)
○ TTE - PAH
§ Annual screening of scleroderma pts with TTE
○ ECG - R) heart strain
○ CXR - enlarged pulmonary arteries
Meds (various) Annual flu + pneumovax Avoid pregnancy due to poor maternal/foetal outcomes
Wolff Parkinson White ECG features (3)
-Delta wave (slurred upstroke of QRS complex)
-Tall R waves
-Inverted T waves V1-V3 (mimicks RVH, but not actually present)
LBBB ECG features (4)
Other conditions impacted re: concurrent diagnosis on ECG (2)
Broad QRS (duration > 120ms)
**Dominant S wave in V1
**Broad monophasic R wave in lateral leads (I, aVL, V5-6)
Absence of Q waves in lateral leads
Ventricular hypertrophy
Myocardial ischaemia/AMI
RBBB ECG features (4)
Briad QRS (duration > 120ms)
RSR’ pattern in V1-3 (“M-shaped” QRS complex)
Wide, slurred S wave in lateral leads (I, aVL, V5-6
ST depression/T wave inversion in right precordial leads (V1-V3)
Prolonging PR interval w/ dropout of QRS ?
vs. intermittent non-conducted P waves without progressive PR prolongation
Mobitz I - Wenckebach
Mobitz II
LVH non-voltage criteria (2)
-Increased R wave peak time V5-V6
-ST segment depression/T wave inversion I, aVL, V5-V6
Also left axis deviation
STEMI territory names for:
-V1-V2
-V3-V4
-V5-V6
-I, aVL
-II, III, aVF
- V12 Anteroseptal
-V34 Anteroapical
-V56 Anterolateral
-I, aVL Lateral
-II, III, aVF Inferior
Anticoagulation withholding timeframes prior to surgery
-Dabigatran/Riva/Apixa
-Aspirin
-Antiplatelets
-Apix/Riva/Dabig - 1-3 days prior to surgery
-Aspirin - ?continue (or WH 7 days prior)
-Antiplatelets - 5-7 days prior
Warfarin - INR <1.5 before surgery, check INR 7 days prior
W/H 3-5 days prior
(Clexane if INR <2 (subtherapeutic))