dermatology

Question 1

Mometasone

Answer 1

topical corticosteroid

antiinflammatory antiasthmatic

use: maintenance for asthma, rhinitis, nasal polyps
how: induces phospholipase A2 inhibitory proteins and inhibits the release of arachidonic acid, therefore inhibiting protaglandins and leukotrienes.. reduce inflammation of the airway and improve pulmonary function
ci: hypersensitivity
se: nasal irritation, burning, headache, pharyngitis, altered sense of smell

Question 2

Isotretinoin

Answer 2

retinoid

use: acne
how: synthetic retinoid which reduces sebaceous gland size and sebum production, also regulates cell proliferation and differentiation
ci: pregnancy X, lactation
interactions: additive toxicity with Vitamin A or derivatives, decreased efficacy of midrodosed progesterone - use 2 forms of contraception, may increase risk of bone loss with phenytoin, may increase risk of osteoporosis with systemic corticosteroids
se: cheilitis (lip inflammation), conjunctivitis, increased ESR, increased TG, decreased HDL, increased LFT, thinning hair, increased platelet cost, prurtitis, epistaxis, skin fragility, dry nose, joint pain

Question 3

Benzoyl peroxide

Answer 3

anti acne antibacterial

use: acne
how: releases active oxygen to kill P acnes and anaerobe, also elicits keratolytic and desquamative effect
se: skin dryness, peeling, erythema, contact dermatitis

Question 4

Permethrin cream

Answer 4

pyrethroid

use: scabies
how: active agains lice, ticks, fleas, mites, scabies.. acts on the nerve cell membrane to disrupt the sodium channel current causing paralysis of the pest
ci: hypersensitivity
se: mild and transient burning and stinging, pruritus

Question 5

Terbinafine

Answer 5

anti fungal, allylamine drug

use: dermatophytosis, onychomycosi of nails, tinea capitis
how: inhibits squalene epoxidase and causes fungal cell death due to increased membrane permeability
ci: hypersensitivity, liver disease, renal disease, lactation
interactions: increased hepatotoxicity with other hepatotoxic drugs, increase effect of SSRI, b blockers, MAOI, warfarin
se: elevator liver function tests, GI disturbances, anorexia, diarrhea, vomiting

Question 6

Calcipotriol

Answer 6

synthetic vitamin D derivative

use: moderate plaque psoriasis

ci; hypersensitivity, use on face, hypercalcemia, hypervitaminosis D, pregnancy

se: burning, itching, skin irritation

Question 7

Selenium Sulfid

Answer 7

antiseborrheic/antifungal

use: tinea versicolor, dandruff, seborrhea
how: not yet known
ci: hypersensitivity, not for eyes, oral, anal, vaginal use

se; stinging, itching, irritation

Question 8

muciprocin

Answer 8

topical antibiotic, protein synthesis inhibitor

use: impetigo caused by staph or streptococci, nasal colonization of S. aureus, infected skin lesion

how: inhibits protein synthesis of the bacteria by binding to isoleucyl transfer RNA
effective against gram positive and some gram neg

ci: burn patients,
se: burning, stinging, itching, erythema, not common