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Skin, Blood, Lymph Exam 2 > Dermatologic Pharmacology (Wolff) > Flashcards

Dermatologic Pharmacology (Wolff) Flashcards

1
Q

What drugs discussed in lecture are used for acne treatments

A

tretinoin

benzoyl peroxide

clindamycin

erythromycin

azaleic acid

tetracycline

oral contraceptives

spironolactone

isotretinoin

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2
Q

Tretinoin

Use & Side effect

A

Use: Topical retinoid for acne vulgaris

Side effect: Local skin irritation, dryness and flaking, sun sensitivity

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3
Q

Benzoyl peroxide

Use & Side effect

A

Use: Topical antimicrobial for acne vulgaris

Side effect: Local skin irritations. May bleach hair or clothing

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4
Q

Clindamycin

Use & Side effect

A

Use: topical antimicrobial for acne vulgaris

Side effect: rare risk of pseudomembranous colitis

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5
Q

Erythromycin

Use

A

Topical antimicrobial for acne vulgaris

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6
Q

What medication kills acne bacteria and decreases the production of keratin

A

Azaleic acid

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7
Q

What is the side effect of using Azaleic acid

A

Local skin irritation

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8
Q

List the oral antibiotics used for treating acne vulgaris

A

Doxycyline, Tetracycline, Minocycline, Azithromycin, Erythromycin, TMP-SMX

Drugs Treat My Acne Every Time

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9
Q

What are the side effects of Tetracycline

A

Photosensitivity, GI distress and contraindicated in pregnancy and young children

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10
Q

What hormonal drug treats acne vulgaris and is especially useful for adult women with menstrual cycle-related breakouts

A

Spironolactone

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11
Q

What are the side effects of spironolactone

A

Contraindicated in pregnancy; menstrual irregularity, breast tenderness, minor gastrointestinal symptoms, orthostatic hypotension, hyperkalemia, dizziness, headaches, fatigue

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12
Q

What oral retinoid used for treating acne vulgaris was discussed in class & what are it’s side effects

A

Oral isotretinoin

Teratogenic (absolutely contrainciated in pregnancy)

Mucocutaneous effects

Hypertriglyceridemia

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13
Q

What drugs were discussed to treat Psoriasis

A

Psoralen

Apremilast

TNF alpha blockers

Ustekinumab

Secukinumab, Ixekuzumab

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14
Q

What do patients ingest 2 hours before the photochemothreapy treatments of Psoriasis

A

Psoralen (plant photosensitizer)

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15
Q

What drug inhibits phosphodiesterase 4 (PDE4) leading to increased cAMP levels in cells

A

Apremilast (Otezla)

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16
Q

What are the side effects of Apremilast (Otezla)

A

severe diarrhea

nausea and vomiting possible

weight loss

headache most common CNS complaint, but depression, suicidal ideation, mood changes have been observe

17
Q

What is the MOA of Ustekinumab (Stelara)

A

Targets proinflammatory cystokines IL-12 and IL-23

18
Q

What are the side effects of Ustekinumab (Stalara)

A
  • generally well tolerated, but increases risk for infections
  • may increase risk for squamous cell carcinomas
  • hypersensitivity reactions
19
Q

What is the MOA of Secukinumab

A

Targets proinflammatory cytokine interleukin 17A

20
Q

What is the side effect of Secukinumab

A
  • generally well tolerated, but increases risk for infections
  • may cause exacerbations of inflammatory bowel disease
  • hypersensitivity reactions
21
Q

What drug is a humanized monoclonal antibody against IL-17A

A

Ixekuzumab

22
Q

What drug used to treat actinic keratosis and warts has two stages of treatment

What are the stages?

A

Imiquimod

Stage 1: Initial disruption of plasma membrane and mitochondria leading to cell necrosis

Stage 2: Neutrophil-meidated antibody dependent cellular tocivity

23
Q

What drug discusses in class is used to treat actinic keratosis & what is it’s MOA

A

MOA - Inhibits thymidylate synthase preventing DNA synthesis casuing inflammation and destruction of lesions

24
Q

What topical medications are used to treat basal cell or squamous cell carcinoma

A

Imiquimod

5-fluorouracil

25
Q

What drug is used to treat advanced basasl cell carcinoma and what is the MOA

A

Vismodegib or sonidegib

Oral Hedgehog signlaing inhibitors

26
Q

What drug is used for the treatment of melanoma and what is it’s MOA

A

Vemurafenib (if BRAF V600D gene mutated)

MAP kinase pathway inhibitor

27
Q

What drugs can be used to treat male pattern baldness and what are their MOAs & side effects

A

Minoxidil - Vasodilates due to K+ channel opening

Finasteride - Inhibits DHT production (can cause sexual dysfunction)

28
Q

What drugs can be used to treat female pattern baldness and what are their MOAs & side effects

A

1ST LINE: Minoxidil - Vasodilates due to K+ channel opening

2ND LINE: Anti-androgens (Spironolactone, finasteride, flutamide)

29
Q

What is the treatment for alopecia

A

Corticosteroids & Topical immunotherapy (DPCP)

Skin, Blood, Lymph Exam 2 (6 decks)

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