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Skin, Blood, Lymph Exam 2 > Cancer Pharmacology (Kruse) > Flashcards

Cancer Pharmacology (Kruse) Flashcards

1
Q

How is mercaptopurine activated

A

Inactive in parent form

Metabolized by HGPRT

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2
Q

What antibodies did we cover in lectures

A

Bevacizumab & Ziv-aflibercept

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3
Q

What antimetabolite purine analog did we discuss in class

A

Mercaptopurine (6-MP)

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4
Q

What antitumor antibiotic causes single and double stranded DNA breaks

A

Bleomycin

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5
Q

What antitumor antibiotic inhibits topoisomerase 2 and intercalates DNA

A

Doxorubicin

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6
Q

What are the common M Phase cell cycle inhibitors we discuses in class and what are their drug classes

A

Natural Antineoplastic Agents

Bleomycin - Antitumor antibiotic

Paclitaxel & Docetaxel - Taxane

Vinblastine & Vincristine - Vinca Alkaloids

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7
Q

What are the side effects of Bleomycin

A

Pulmonary toxicities

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8
Q

What are the side effects of Vinblastine

A

Alopecia

Bone marrow supression

Myelosuppression to a great extent than vincristine

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9
Q

What are the side effects of Vincristine

A

Alopecia

Bone marrow supression

Cumulative neurologic toxicities to a greater extent than vinblastine

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10
Q

What drug binds to beta tubulin and inhibits microtubule assembly (depolarization)

A

Vinblastine & Vincristine

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11
Q

What drug category is carmustine

A

Nitrosourea - Alkylating agent

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12
Q

What drug class are Vinblastine & Vincristine

A

Vinca Alkaloids

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13
Q

What drug class in Ziv-aflibercept

A

Tyrosine Kinase growth factor receptor inhibitor

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14
Q

What drug class is Doxorubicin

A

Anthracycline

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15
Q

What drug inhibits the BCR-ABL fusion protein & what is it’s MOA

A

Imatnib

Inhibits the ABL tyrosine kinase

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16
Q

What drug is a calcium channel blocker that inhibits P-glycoprotein transporters

A

Verapamil

17
Q

What drug is used as an implantable wafer in the brain to treat malignant glioma as an adjunct to surgery and radiation

A

Carmustine

18
Q

What drug reduces the toxic side effects of methotrexate

A

Leucovorin

19
Q

What drugs are associated withe the p-glycoprotein resistance mechanism & what are their MOA

A

Vinca alkaloids

Etoposide & anthracyclines - Inhibit topoisomerase 2

Paclitaxel

Dactinomycin - intercalates DNA

20
Q

What drugs bind to beta tubulin and stabilize microtubule formation

A

Paclitaxel, Docetaxel & Cabazitaxel

21
Q

What enzyme metabolizes mercaptopurine to the inactive metabolite

A

Xanthine oxidase (first pass)

22
Q

What is the adverse side effect of Doxorubicin

A

Cardiovascular toxicity from production of free radicals

23
Q

What is the drug class of Paclitxael, Docetaxel & Cabazitaxel

A

Taxanes

24
Q

What is the MOA of Bevacizumab

A

Monoclonal antibody that binds to VEGF-A preventing ligands from binding to it

25
Q

What is the MOA of ziv-aflibercept

A

Binds VEGF-A, VEGF-B and prevents them from binding to VEGF receptor

Also binds PIGF

26
Q

What is the side effect of Docetaxel

A

Hypersensitivity, neutropenia and hair loss

27
Q

What is the side effect of Paclitaxel

A

Hypersensitivity reactions in hands and toes

Change in taste

28
Q

What taxane avoids the mechanism of resistance of P-glycoprotein

A

Cabazitaxel

29
Q

Which taxane has a greater cellular uptake and is retained intracellularly longer, leading to smaller dose and less side effects

A

Docetaxel

Skin, Blood, Lymph Exam 2 (6 decks)

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