Dermato Flashcards
A newborn WB foal presented with ligament hyperlaxity and numerous skin lesions. What is your clinical diagnosis? What other breeds are affected?
Fragile foal syndrome type 1 (FFS), formerly warmblood fragile foal syndrome (WFFS), is an inherited defect of connective tissue characterized by hyperextensible, abnormally thin, fragile skin and mucous membranes that are subject to open lesions.
Affected horses may also have hyperextensible limb joints, floppy ears, accumulation of fluid (hydrops), subcutaneous emphysema, hematomas, and premature birth.
The disease is present at birth and affected newborn foals are euthanized shortly after birth due to the poor prognosis of this untreatable condition.
Fragile foal syndrome type 1 is an autosomal recessive disease, mutation in the PLOD1 gene.
The FFS mutation has been reported in warmblood breeds and is at a low frequency in Thoroughbreds.
