Derm: topical or oral antibiotic

Question 1

Indications of topical or oral antibiotic?

Answer 1

Acne vulagaris

Question 2

MOA of topical or oral antibiotic?

Answer 2

Inhibits bacterial protein synthesis.

Question 3

Adverse effects of topical or oral antibiotic?

Answer 3

Skin irritations
Dryness
Urticaria
Erythema

GI disturbances
Colitis

Question 4

Warnings of topical or oral antibiotic?

Answer 4

Topical:
- Don’t prescribe in hypersensitivity.
- Caution in IBD, atopic conditions, or abx-associated colitis.
- If diarrhoea occurs, stop medication.
- use in pregnancy if needed.

Oral:
- Avoid in hypersensitivity.
- Most tetracyclines are contraindicated in pregnancy, breastfeeding, and children age <12.
- Avoid tetracyclines in myasthenia gravis, SLE, hepatic and renal impairment.

Topical abx should be prescribed with benzoyl peroxide due to risk of abx resistance.

Question 5

Interactions of topical or oral antibiotic?

Answer 5

Systemic absorption can follow topical applications consider any interactions.

Question 6

Monitoring of topical or oral antibiotic?

Answer 6

Check if acne has improved.

Question 7

Pt educations of topical or oral antibiotic?

Answer 7

Applications of topical abx is usually once or twice a day.