Derm: Azelaic acid, Topical steroid cream Flashcards
Indications of azelaic acid?
Acne vulagaris
MOA of azelaic acid?
Antibacterial effects by inhibiting synthesis of cellular proteins in anaerobic and aerobic bacteria.
(Azelaic acid is naturally found in grains such as barley, wheat and rye -antimicrobial and anti-inflammatory properties.)
Adverse effects of azelaic acid?
Blistering
Flaking
Irritation
Swelling
Pruritus
Changes in skin colour
Worsening of asthma (rare)
Warnings of azelaic acid?
Avoid in hypersensitivity to the active substance.
Avoid contact with eyes, mouth, and with mucous membranes.
Caution if prescribing to pregnant or breastfeeding women.
Interactions of azelaic acid?
None
Monitoring of azelaic acid?
Assess acne to see if there is improvement in symptoms.
Pt education of azelaic acid?
Avoid alcohol.
May cause flushing, therefore it may worse rosacea.
Indications of topical steroid cream?
Eczema
MOA of topical steroid cream?
Has immunosuppressive, metabolic and mineralcorticoid effects.
Topical corticosteroids can be classified as:
- mild
- moderately potent
- very potent
(depends on conc and the type).
Adverse effects of topical steroid cream?
Local adverse effects of potent and very potent topical corticosteroids can cause:
- skin thinning
- striae
- telangiectasia
When used on face:
- perioral dermatitis
- cause or exacerbate acne
Withdrawal of topical corticosteroids:
- rebound worsening of underlying skin condition
- adrenal suppression (rare)
- systemic adverse effects
Warnings of topical steroid cream?
Do not use where infection is present -can worsen the infection or spread.
Do not use potent corticosteroids on facial lesions present AND treatment courses should be short.
Interactions of topical steroid cream?
None.
If several topical agents are being used on the same area of skin, applications should be spaced out to allow absorption of pharmacologically active agents.
- Emollients should be applied LAST.
Monitoring of topical steroid cream?
Review pt 1-2 wks of tx and check for improvement in symptoms and if following tx instructions correctly.
Pt education of topical steroid cream?
Aims to relieve inflammation and improve their skin problem.
Will have a full effect in 1-2 weeks.
Inform how and when to apply the typical corticosteroid and that emollients should be applied 5mins after this.
Warn risk of skin damage if tx applied to wrong areas
Examples of topical steroid cream?
Hydrocortisone
Betamethasone
