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Derm/Other Flashcards

1
Q

Atopic dermaatitis - deficiency of what molecule?

A

Filaggarin

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2
Q

Small bowel features on XR

A

Lines whole way through - valvulae conaventes

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3
Q

Large bowel features XR

A

Partial lines - haustra

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4
Q

Is bowel dilated? - rule?

A

3-6-9
Normal diametes
- 3cm small bowel
- 6cm - large bowel
-9cm - caecum

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5
Q

SOB and dry cough 6 weeks after radiotherapy for met breast cancer
- ?Dx
- ?Rx

A

Radiation induced lung injury

Treatment - prednisolone

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6
Q

Which antipsychotic least associated with photosensitiviy?

A

Aripiprazole

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7
Q

White out lung, trachea pushed towards white out
- causes

A

Lung collapse
Pneumonectomy

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8
Q

White out lung, trachea pushed away from white out

A

Pleural effusion
Pulmonary mass
Hernia

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9
Q

White out lung, trachea middle

A

Consolidation
Pulmonary oedema/ARDS

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10
Q

What defines a tension pneumothorax?

A

Pneumothorax with clinical instability - low BP, low sats, high RR, clinical tracheal deviation

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11
Q

Bilateral hilar lymphadenopathy - cause?

A

Sarcoid

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12
Q

Unilateral hilar lymphadenopathy - cause?

A

TB

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13
Q

Which mineral can result in raised intracranial pressure?

A

Retinol

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14
Q

Dix Hallpike - testing for which canal in BPPV?

What finding?

A

Posterior canal BPPV

Testing for torsional nystagmus

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15
Q

Horizontal canal BPPV - what type of nystagmus?

A

Horizontal

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16
Q

Cause of hyerptonic hyponatremia

A

Hypergylcaemia
Mannitol
IVIG

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17
Q

Causes of pseudohyponatremia

A

Lipemic serum
Obstructive jaundice
Plasma cell dyscrasia

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18
Q

Thunderstorm asthma
- previous exposure

A

Rye grass

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19
Q

Most pathogenic autoantibody?

A

IgG

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20
Q

Ab association of amyopathic dermatomyositis

A

MDA-5

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21
Q

CK4 and CK14 - which cell origin?

A

Epithelial

22
Q

Anti-epileptic causing reduced bone density

23
Q

G6PD produces what to prevent from oxidative injury?

24
Q

Granular deposits IgA in skin?

A

Dermatitis herpetiformis

25
Q

1st line treatment dermatitis herpetiformis

A

Gluten avoidance
Dapsone

26
Q

Pregnant and bipolar - which medication to reduce manic episodes?

A

Antipsychotics

27
Q

Lifetime risk of depression reucrrence

28
Q

Lobar ICH

A

CAA - particularly if old

29
Q

HSCT
<D30
LFT derangement

A

Veno-occlusive disease

30
Q

Loss of joint space at base of thumb (carpometocarpal joint)

31
Q

Loss of joint space 2nd and 3rd metacarpophalangeal joints

A

Haemachromatosis

32
Q

Correlates with visceral adipose tissue?

A

Waist circumference

33
Q

Main receptor target of antipyschotics

33
Q

Malignant bowel obstruction - managed symptoms?

A

Octreotide

34
Q

1st management of bullous pemphigoid

A

TOpical steroids

35
Q

Immune mediated necrotising myopathy vs statin induce myoncerosis

A

Inflammatory infiltrate for immune mediated - MHC1 and complement

36
Q

Dark coarse granulated WCC on blood film

37
Q

Common autoimmune manifestation of C1q deficiency

38
Q

Other name for transcobalamin 1

A

R protein or haptocorrin

39
Q

Neurogenic spinal canal stenosis vs vascular claudicaton
- tingling/weakness?
- relief standing erect?
- Relief when flexed
-

A

Neurogenic
- Has tingling
- Does not have relief with standing erect
- Relief with flexing

40
Q

PD-1 inhibitors

A

Pembrolizumab
Nivolumab

41
Q

PD-L1 inhibitors

A

Atezoliumab
durvulamab

42
Q

Checkpoint which enhances TReg activity?

A

LAG3

  • LAG3 blockers reactivate immune system - relatlimab
43
Q

FABER test

A

Flexio, ABduction, external rotation

Specific for greater trochanteric pain syndrome/Hip pathology

44
Q

Which medication displaces plasminogen to stabilise clot?

A

Tranexamic acid

Also reduces C1 esterase consumption so minimises symptoms of HAE

45
Q

BNP
- Reduces sensitivity?
- Reduces specificity?

A

Sensitivity - Obesity (tend to have lower BNP)

Specificity - renal failure, tend to have higher BNP

46
Q

B2MG - what structure?

47
Q

Weight loss OHG’s

A

GLP-1
SGLT2

48
Q

Weight gain OHG’s

A

Insulin
Sulfonylureas
Piaglitizone

49
Q

Weight neutral OHG’s

A

DPP4
Acarbose
Weight neutral

50
Q

Second wind phenomenon, fatigue with excercise

A

MCardle disease

51
Q

Taxanes act at which cell cycle phase?

BPT (18 decks)

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