Derm/Other

Question 1

Atopic dermaatitis - deficiency of what molecule?

Answer 1

Filaggarin

Question 2

Small bowel features on XR

Answer 2

Lines whole way through - valvulae conaventes

Question 3

Large bowel features XR

Answer 3

Partial lines - haustra

Question 4

Is bowel dilated? - rule?

Answer 4

3-6-9
Normal diametes
- 3cm small bowel
- 6cm - large bowel
-9cm - caecum

Question 5

SOB and dry cough 6 weeks after radiotherapy for met breast cancer
- ?Dx
- ?Rx

Answer 5

Radiation induced lung injury

Treatment - prednisolone

Question 6

Which antipsychotic least associated with photosensitiviy?

Answer 6

Aripiprazole

Question 7

White out lung, trachea pushed towards white out
- causes

Answer 7

Lung collapse
Pneumonectomy

Question 8

White out lung, trachea pushed away from white out

Answer 8

Pleural effusion
Pulmonary mass
Hernia

Question 9

White out lung, trachea middle

Answer 9

Consolidation
Pulmonary oedema/ARDS

Question 10

What defines a tension pneumothorax?

Answer 10

Pneumothorax with clinical instability - low BP, low sats, high RR, clinical tracheal deviation

Question 11

Bilateral hilar lymphadenopathy - cause?

Answer 11

Sarcoid

Question 12

Unilateral hilar lymphadenopathy - cause?

Answer 12

TB

Question 13

Which mineral can result in raised intracranial pressure?

Answer 13

Retinol

Question 14

Dix Hallpike - testing for which canal in BPPV?

What finding?

Answer 14

Posterior canal BPPV

Testing for torsional nystagmus

Question 15

Horizontal canal BPPV - what type of nystagmus?

Answer 15

Horizontal

Question 16

Cause of hyerptonic hyponatremia

Answer 16

Hypergylcaemia
Mannitol
IVIG

Question 17

Causes of pseudohyponatremia

Answer 17

Lipemic serum
Obstructive jaundice
Plasma cell dyscrasia

Question 18

Thunderstorm asthma
- previous exposure

Answer 18

Rye grass

Question 19

Most pathogenic autoantibody?

Answer 19

IgG

Question 20

Ab association of amyopathic dermatomyositis

Answer 20

MDA-5

Question 21

CK4 and CK14 - which cell origin?

Answer 21

Epithelial

Question 22

Anti-epileptic causing reduced bone density

Answer 22

Phenytoin

Question 23

G6PD produces what to prevent from oxidative injury?

Answer 23

NADPH

Question 24

Granular deposits IgA in skin?

Answer 24

Dermatitis herpetiformis

Question 25

1st line treatment dermatitis herpetiformis

Answer 25

Gluten avoidance Dapsone

Question 26

Pregnant and bipolar - which medication to reduce manic episodes?

Answer 26

Antipsychotics

Question 27

Lifetime risk of depression reucrrence

Answer 27

50%

Question 28

Lobar ICH

Answer 28

CAA - particularly if old

Question 29

HSCT

Answer 29

Veno-occlusive disease

Question 30

Loss of joint space at base of thumb (carpometocarpal joint)

Answer 30

OA

Question 31

Loss of joint space 2nd and 3rd metacarpophalangeal joints

Answer 31

Haemachromatosis

Question 32

Correlates with visceral adipose tissue?

Answer 32

Waist circumference

Question 33

Main receptor target of antipyschotics

Answer 33

D2

Question 33

Malignant bowel obstruction - managed symptoms?

Answer 33

Octreotide

Question 34

1st management of bullous pemphigoid

Answer 34

TOpical steroids

Question 35

Immune mediated necrotising myopathy vs statin induce myoncerosis

Answer 35

Inflammatory infiltrate for immune mediated - MHC1 and complement

Question 36

Dark coarse granulated WCC on blood film

Answer 36

Think CML

Question 37

Common autoimmune manifestation of C1q deficiency

Answer 37

SLE

Question 38

Other name for transcobalamin 1

Answer 38

R protein or haptocorrin

Question 39

Neurogenic spinal canal stenosis vs vascular claudicaton - tingling/weakness? - relief standing erect? - Relief when flexed -

Answer 39

Neurogenic - Has tingling - Does not have relief with standing erect - Relief with flexing

Question 40

PD-1 inhibitors

Answer 40

Pembrolizumab Nivolumab

Question 41

PD-L1 inhibitors

Answer 41

Atezoliumab durvulamab

Question 42

Checkpoint which enhances TReg activity?

Answer 42

LAG3 - LAG3 blockers reactivate immune system - relatlimab

Question 43

FABER test

Answer 43

Flexio, ABduction, external rotation Specific for greater trochanteric pain syndrome/Hip pathology

Question 44

Which medication displaces plasminogen to stabilise clot?

Answer 44

Tranexamic acid Also reduces C1 esterase consumption so minimises symptoms of HAE

Question 45

BNP - Reduces sensitivity? - Reduces specificity?

Answer 45

Sensitivity - Obesity (tend to have lower BNP) Specificity - renal failure, tend to have higher BNP

Question 46

B2MG - what structure?

Answer 46

MHC1

Question 47

Weight loss OHG's

Answer 47

GLP-1 SGLT2

Question 48

Weight gain OHG's

Answer 48

Insulin Sulfonylureas Piaglitizone

Question 49

Weight neutral OHG's

Answer 49

DPP4 Acarbose Weight neutral

Question 50

Second wind phenomenon, fatigue with excercise

Answer 50

MCardle disease

Question 51

Taxanes act at which cell cycle phase?

Answer 51

M