Derm Flashcards
MOA
tacrolimus (Protopic)
pimecrolimus (Elidel)
calcineurin inhibitors; macrolide immunosuppressants;
MOA= inhibit T-lymphocyte activation & prevent the release of inflammatory cytokines after stimulation by antigen-IgE complexes
MOA
tretinoin
topical vitamin A analogue;
comedolytic: increases cell turnover in the follicular wall causing extrusion of existing comedones and inhibition of new comedone formation
MOA
adapalene
- third-generation retinoid
- retinoidmimetic compound (a naphthoic acid derivative)
- selective affinity for retinoic acid receptor (RAR) subtypes RAR-b and RAR-y found in epidermis
- comedolytic, keratolytic, and antiinflammatory activity
MOA
tazarotene
- prodrug and a synthetic acetylenic retinoid
- coverted to tazarotenic acid (active form) after topical application
- selectively binds to RARs and can alter expression of genes involved in cell proliferation, cell differentiation, and inflammation
-comedolytic, keratolytic, and antiinflmatory activity
MOA
topical abx: erythromycin and clindamycin
bactericidal against P. acnes;
comedolytic & anti-inflammatory action
MOA benzoyl peroxide (BPO)
comedolytic: increases the sloughing rate of epithelial cells, loosens the follicular plug structure (unclogs pores)
MOA
dapsone (Aczone)
antiinflammatory & antibacterial activity;
improves inflammatory and noninflammatory lesions, but more efficacious in inflammatory
MOA
sulfur
keratolytic, mildly antibacterial, exfoliant action
MOA
oral abx for acne
inhibit growth of P. acnes;
comedolytic and anti-inflammatory rxn
MOA
oral contraceptives for acne
inhibits production of androgens
MOA
isotretinoin
- induction of atrophy of the sebaceous gland w/ decreased sebum production and change in sebum composition
- inhibition of P. acnes growth within follicles
- inhibition of inflammation
- altered patterns of keratinization within follicles (decreased size and increased differentiation)
salicylic acid: MOA
keratolytic
topical retinoids: contraindications
<12 y/o, pregnancy
Isotretinoin: contraindications
- psych disorders
- hyperlipidemia
- diabetes
- severe osteoperosis
Isotretinoin: required monitoring
- pregnancy test (females)
- lipid test
- liver function
- CBC
- CMP