Derm

Question 1

Hydrocortisone

Answer 1

• steroid
• used to dermatitis, psoriasis
• adverse effects= atrophy/thinning of skin (collagen), stretch marks, telangiectasias, cataract or glaucoma if applied near eye
• systemically affects HPA axis –> growth retardation
• seven classes (I is the strongest)

Question 2

cyclosporine

Answer 2

• immunosuppressant
• used to treat psoriasis (inflamm conditions)
• HTN, kidney damage if long-term use

Question 3

Methotrexate

Answer 3

• folate analog –> inhibits DHFR –> inhibits cell division; also has some immunosuppressant activity
• psoriasis and other inflamm conditions
• hepatotoxicity develops slowly (need to monitor LFTS), pulmonary toxicity can develop quickly

Question 4

Biologics

Answer 4

• block TNF-alpha
• arthritis (rheumatoid and psoriatic) and othe rinflamm conditions
• may halt disease progression

Question 5

UV light therapy

Answer 5

• immunosuppression of T cells
• inflamm conditions: atopic dermatitis, lichen planus, psoriasis
• usually with psoralens (photosensitizing agents that increase efficacy)

Question 6

Isotretinoin (accutane)

Answer 6

• retinoid
• stimulate epithelial cell turnover; also anti-inflammmatory
• acne
• teratogenic affects (washes out in 3 weeks)

Question 7

Acitretin (Soriatane)

Answer 7

• Retinoid
• stimulate epi cell turnover; also anti-inflammatory
• psoriasis
• teratogenic effects (stays in fat stores for 3 years!)