Depressive, Bipolar and related disorders Flashcards
withdrawal and discontinuation syndrome with antidepressants
- physical symptoms (dizziness, diarrhea, insomnia)
- psychological symptoms (anxiety, agitaiton, confusion)
- titrate dose to prevent this
when does bipolar disorder develop
- late teens or early adulthood
- moslty before 25
what should be monitored when taking SSRIs
- thyroid function
- side effects
- therapuetic effects
- watch for suicideal thoughts, hypomania, disinhibition
what needs to happen to be diagnosed with disorder
- affects daily activities and QOL
what needs to be monitored when on lithium
- lithium levels in the blood (0.8-1.2)
what is the leading helath problem of 21st centery
- depressive disorder
what is prefrontal cortex responsible for (neuroanatomical)
congnition
- decision making
what is it called when major depressive episode and dysthymic overlap
double depression
what do you monitor for when on carbamazepine
- agranulocytosis
- SJS
what do SSRIs do:
- increase serotonergic activity
- decrease action of presynaptic reuptake pump
- allows neurotransmitters to stay in synapse
what diagnostics for persisitant depressive disorder
- 2 or more symptoms for a year
what criteria is needed to be diagnosed with MDD
- 5 or more symptoms for 2 week span
Volproates (anticonvulsants) monitoring
- thrombocytopenia
- extensive hepatic excretion
TCAs monitoring:
- cardiac screening
- serum potassium
TCAs MOA
block reuptake of serotonin and norepineprhine
SNRIs treat depression by:
- inhibiting reuptakes of serotonin and norepineprhine
- increased stimulation of post-synaptic receptors
side effects of TCAs
- orthostaic hypotension
- diaphoresis
- sedation
- cardiac toxicity
- seizures
serotonin modulators side effects
- nausea
- fatigue
- dry mouth
- constipation
- weakness
serotonin modulators MOA
- impacts serotonin, modulate one or more serotonin receptors and inhibit reuptake of serotonin
S/E of SNRIs
- nausea
- dizziness
- diaphoresis -
- increased BP/HR
S/E of lithium carbonate
- tremor, polyuria, polydispsia, weight gain, diarrhea
risk factors
- prior episodes
- family history
- lack social support
- stress
- economic difficulties
remission
- minimal to no symptoms for more than 2 months
relapse
- a return to fully symptomatic state during remission