Depression (Orange Deck) Flashcards
stimulation of which receptor causes SSRI-sexual dysfunction and what can be given to rectify
5-HT2 receptor; cyproheptadine
Depression is the major cause of ____ (2 reasons)
- work days lost to disability
- premature death
why we cannot conclude that all drugs work by the monoamine theory
- monoamines are important in the drug MOA
BUT - there are complex interactions w other neurotransmitter systems as well
which MAO selective inhibitors are used in Parkinson’s disease?
MAO-B selective inhibitor
How do we prevent/ lessen the occurrence of cheese reaction when taking MAO inhibitors
use a more selective, MAO-A inhibitor + reversible (moclobemide) than a non-selective + irreversible MAO inhibitor (phenelzine)
Two different types of TCAs (2 forms)
Non-selective for SERT/NET: imipramine, amitriptyline, nortriptyline
Selective for NET: desipramine
Which was the first class of drug to be developed for the purpose of antidepressant treatment?
SSRI
2 drug names under SSRI and their selectivity towards 5-HT receptors
- fluoxetine = 50-fold selectivity for 5-HT
- citalopram = 1000-fold selectivity for 5-HT
fluoxetine most widely used
Advantage of SSRI over e.g. TCAs
fewer adverse effects than TCA
safer in overdose and thus better compliance
Which SSRI can still cause some sedation due to what receptor antagonism?
citalopram, due to histamine receptor antagonism
Which NARI is not used and what adverse effect it had
Maprotiline - an earlier NARI –> TCA-like adverse effect due to a-adrenoreceptor and histamine receptor effects and occasionally seizures
3 SNRI drugs
venlafaxine, desvenlafaxine, duloxetine
Mirtazapine MOA
antagonism of adrenergic alpha 2 receptor and specific 5-HT2c receptor (NaSSA)
noradrenergic and specific serotonergic antidepressant
Bupropion MOA
NE-Dopa reuptake inhibitor
Agomelatine, MOA and specially used in
agonist of melatonin MT1 and MT2 receptors and antagonism of 5-HT2C receptor
less TCA/SSRI-assoc SE
used in sleep disorders
