Depression Flashcards
lifetime prevalence of depression
16% (#1 new dx in primary care)
big RF’s for suicide?
biggest RF?
M + >65
past attempt
RF’s for depression
Family hx Personal hx Female Stressful events Lack of support Loss of parents early on Child abuse Substance use Anxiety Medical conditions
Classic stroke assoc w depression?
Left frontal lobe
lifetime risk for depression (M v F)
10% men
20% women
stressful life event can increase risk of depression by?
9x
stressful life event vs depressive episodes
link weakens as depression develops into a chronic illness i.e. you don’t need an event to cause a new depressive episode
DSM criteria for MDD
SIGECAPS
Sleep (insomnia/hypersomnia) Interest (/pleasure) Guilt (worthless) Energy (mood) Concentration (indecisive) Appetite (weight) Psychomotor (agitatn/retardatn) Suicidal
persistent depressive disorder
dysthmic disorder
part of anterior cingulate that’s below the genu
subgenual PFC
part of cortex deep w/in brain, connects superior parts (frontal/parietal) with temporal, important for representation of bodily states
insula
what part of brain regulates amygdala activity?
VMPFC
more activity in VMPFC, less activity in amygdala
this control is loosened in depression, and actually a POSITIVE relationship is seen
fxnl/structural brain adaptations to the environment
plasticity
experience-dependent
cells that fire together wire together (who’s law?)
learning/adaptive behavior
activity-dependent neuroplasticity (Hebb’s Law)
experience-dependent NP
plasticity enhanced by?
psychotherapy antidepressanys ECT/DBS Exercise Phototherapy Omega-3's
