Depression Flashcards
What drugs affect the serotonin transporter?
Citalopram
Venlafaxine
Sertraline
Fluoxetrine
What drug (classes) affect noradrenaline transporter?
Venlafaxine
What drug classes affect alpha 2- receptor?
Mirtazapine
What drug class affects 5 HT2 receptor?
Mirtazapine
What are the side effects of the drugs that affect the serotonin transporter?
GI side effects, sexual dysfunction, anxiety, insomnia
what are the side effects of the drugs that affet the noradrenaline transporter?
GI side effects, anxiety, insomnia, sexual dysfunction, hypertension
What are the side effects of Mirtazapine?
Weight gain, sedation
Extra information on Citalopram
Mild antagonism of muscuranic and histamine receptor (H1)
Decrease gradually on discontinuation
Metabolised by CYP2C19
Extra information on Fluoxetine
Mild antagonism of 5HT2A & 5HT2C receptor
Complete inhibition of CYP2D6 and significant inhibition of CYP2C19 ( be careful with warfarin)
Extra information sertraline
Mild inhibition of dopamine transporter
Must be decreased gradually on discontinuation
Partial inhibition of CYP2D6
Extra information Venlofaxine
gradually decrease on discontinuation
Extra information Mirtazapine
Low probability of sexual dysfunction
May exacerbate REM sleep behaviour disorder
Mechanism of action of drugs acting on serotonin transporter
Inhibition of serotonin reuptake
Accumulation of serotonin
Mechanism of action of drugs acting on noradraline transporter
Inhibition of noradrenaline reuptake
accumulation of noradrenaline
Mechanism of action of Mirtazapine
Antagonises central presynaptic alpha 2 adrenergic receptor , increases releases of noradrenaline and serotonin
antagonises central 5HT2 receptors , 5HT2 receptors unopposed , antidepressant effect
