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PHARMACOLOGY > Depression > Flashcards

Depression Flashcards

1
Q

Describe the mechanism of action for Setraline/

A

Inhibition of serotonin reuptake results in an accumulation of serotonin.
Serotonin in the central nervous system plays a role in the regulation of mood, personality, and wakefulness.

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2
Q

What is the drug target of setraline?

A

Serotonin transporter

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3
Q

What are the side effects of Setraline?

A

GI effects (nausea, diarrhoea), sexual dysfunction, anxiety, insomnia

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4
Q

What is important to consider when discontinuing Setraline?

A

Must be gradually decreased on discontinuation. Partial inhibition of CYP2D6 at high doses (150 mg).

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5
Q

Describe the mechanism of action of Citalopram?

A

Inhibition of serotonin reuptake results in an accumulation of serotonin. Serotonin in the central nervous system plays a role in the regulation of mood, personality, and wakefulness.

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6
Q

What other receptor is citalopram an antagonist for?

A

Mild antagonism of muscarinic and histamine (H1) receptors

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7
Q

Which drugs are SSRI’s?

A

Setraline
Citalopram
Fluoxetine
Venlafaxine
Mirtazapine

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8
Q

What is the mechanism of action of Mirtazapine?

A

Antagonises central presynaptic alpha-2-adrenergic receptors, which causes an increased release of serotonin and norepinephrine.
Antagonises central 5HT2 receptors, which leaves 5HT1 receptors unopposed causing anti-depressant effects.

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9
Q

What are the drug targets of Mirtazapine?

A

Alpha - 2 receptor
5 - HT2 Receptor

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10
Q

What are the side effects of Mirtazapine?

A

Weight gain, sedation

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11
Q

What is the effect of Mirtazapine on sleep?

A

May exacerbate REM sleep behaviour disorder

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12
Q

Why is mirtazapine preffered over oher SSRI’s?

A

Low probability of sexual dysfunction.

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13
Q

What is the mechanism of action for venlafaxine?

A

Venlafaxine is a more potent inhibitor of serotonin reuptake than norepinephrine reuptake.
Noradrenaline in the central nervous system is implicated in the regulation of emotions and cognition.

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14
Q

Which receptors does Venlafaxine act on?

A

Serotonin transporter

Noradrenaline transporter

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15
Q

What are the side effects of Venlafaxine?

A

GI effects (nausea, diarrhoea), sexual dysfunction, anxiety, insomnia, hypertension (at higher doses)

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PHARMACOLOGY (5 decks)

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