Depression Flashcards

1
Q

What is the DSM?

A

American Psychiatric Association’s “Diagnostic and Statistical Manual of
Mental Disorders”

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2
Q

What is the Kraepelinian definition of MDI?

A

ANY recurrent mood episodes of any kind

[depressive OR manic] constituted the diagnosis of MDI

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3
Q

What defines an illness as a mood disorder as supposed to an affective disorder?

A

fundamental disturbance is a change in affect or
mood to depression (with or without associated anxiety) or to elation

usually accompanied by a change in the
overall level of activity

tend to be recurrent and the onset of
individual episodes can often be related to stressful events or situations

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4
Q

What is MDD?

A

Major depressive disorder

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5
Q

What is the prevalence of MDD?

A

10-20% lifetime rate

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6
Q

What is the difference between sex in depression?

A

Twice as many woman suffer depression

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7
Q

What is the impact of Mental health numerically?

A

7% of disability adjusted life years

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8
Q

What is the typical cycle of low mood?

A

Thoughts - what’s the point?
Feelings - low, flat, irritable
Physiological symptoms - exhaustion
Behaviours - lie in bed all day

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9
Q

What is the DSM-5 criteria for depressive episode?

A

Occurrence of 2 weeks or more of depressed mood
AND the presence of 4 of 8 out of the following:
• Sleep alterations (insomnia or hypersomnia)
• Appetite alterations (increased or decreased)
• Diminished interest or anhedonia
• Decreased concentration
• Low energy
• Guilt
• Psychomotor changes (agitation or retardation)
• Suicidal thoughts

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10
Q

What are the core symptoms of depression?

A

Low mood
Low energy
Anhedonia

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11
Q

When is MDD diagnosed?

A

If no manic or hypomanic episodes in the past are identified, then the diagnosis of a
current major depressive episode leads to a longitudinal diagnosis of Major Depressive
Disorder (MDD)

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12
Q

What are the DSM subtypes for depression?

A
Atypical features (which represent mainly increased sleep and appetite, along
with heightened mood reactivity)
• Melancholic features (defined by no mood reactivity, along with marked
psychomotor retardation and anhedonia)
• Psychotic features (the presence of delusions/hallucinations).
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13
Q

What are the biological symptoms of depression?

A

Sleep
Libido
Appetite

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14
Q

What are the psychological symptoms of depression?

A

The world
Oneself
The future

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15
Q

What is a typical cycle of high mood?

A

Thoughts - I’m the best
Feelings - elation, excitement
Psychological - increased energy, race sensation
Behaviours - impulsive, increased activity

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16
Q

What are the DSM diagnosis criteria for Mania/Bipolar?

A

Euphoric or irritable mood with 3 or more of 7 manic criteria:

  • Decreased need for sleep with increased energy
  • Distractibility
  • Grandiosity or inflated self-esteem
  • Flight of ideas or racing thoughts
  • Increased talkativeness or pressured speech
  • Increased goal-directed activities or psychomotor agitation
  • Impulsive behaviour (such as sexual impulsivity or spending sprees)
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17
Q

What is the time frame for diagnosis of mania/bipolar?

A

minimum 1 week with notable functional
impairment leading to a DSM-5 diagnosis of type I
bipolar disorder

minimum 4 days, but without notable functional
impairment, a hypomanic episode is diagnosed

less than 4 days, or if other specific thresholds are not met for
manic or hypomanic episodes, then
“Unspecified Bipolar Disorder”

18
Q

When is type II bipolar disorder diagnosed?

A

only hypomanic episodes are
present, along with at least one major depressive episode, then the DSM-5 diagnosis of
type II bipolar disorder is made

19
Q

What can manic episodes be characterised by?

A

psychotic features e.g. delusions/hallucinations

20
Q

What can hypomania not be diagnosed?

A

If psychotic features are present

If patient is hospitalised

21
Q

What is the Bipolar II?

A

Less elation

Greater depressive episodes

22
Q

What is cyclothymia

A

‘mood swings’

not huge either way

23
Q

What are the stats for the first episode in bipolar I?

A

85% have a depressive as first
episode
• 10% a manic episode
• 3-5% mixed episode

24
Q

What must not be ignored in people with bipolar disorder?

A

Anxiety

30-70% of bipolar patients
Worse prognosis and outcomes

25
What are the similarities between bipolar and unipolar illness?
MDD is also diagnosed young MDD is also recurrent Genetics had found frequency occurrence of bipolar illness in relatives of those with unipolar depression Treatments overlap Lithium effective in both unipolar and bipolar types
26
What are the differences between bipolar and unipolar illness?
Bipolar is has higher heritability | Insight is preserved in depression but impaired in mania
27
What are the features of attention bias in depression?
Attention biases more typical of anxiety Depression is characterised by biases in maintaining/shifting attention = difficulties for depressed people to disengage from negative material
28
What imaging is used in depression?
Functional MRI works by detecting the changes in blood oxygenation and flow that occur in response to neural activity
29
What does a fMRI show in depression?
Sustained amygdala response to negative stimuli Prefrontal cortex: • perigenual anterior cingulate cortex (ACC) (BA 24, 25, and 32) appears to mediate negative attentional biases • lateral inferior frontal cortex associated with the impaired ability to divert attention from task-irrelevant negative information
30
What is memory bias?
Preferential recall of negative compared to positive material = one of the most robust findings in the depression literature
31
What memory bias is seen in depression?
Bias: Toward negative material or Away from positive material
32
What perceptual biases are present in those with depression?
Increased recognition of negative faces AND/OR Decreased recognition of happy faces
33
What happens when someone with depression passively views emotional facial expressions?
Enhanced amygdala response to negative faces
34
What is the amygdala?
medial temporal lobe region is involved in the perception and encoding of stimuli relevant to current or chronic affective goals, ranging from rewards or punishments to facial expressions of emotion to aversive or pleasant images and films. While amygdala generally is sensitive to detecting and triggering responses to arousing stimuli, it exhibits a bias towards detecting cues signalling potential threats, like expressions of fear
35
How has Facial expression recognition modulation | by antidepressants been studied?
Healthy volunteers models Acute single dose Neurofunctional: both increased and reduced amygdala response to SSRIs
36
What is serotonin?
NT in brain 14 different serotonin receptors Found all over the brain
37
What is the 'monoamine deficiency hypothesis'?
postulates that depressive symptoms arise from insufficient levels of monoamine neurotransmitters serotonin (or 5-hydroxytryptamine , 5-HT), norepinephrine, and/or dopamine
38
What is serotonin also known as?
5-HT
39
What is the indirect evidence of 5-HT hypo-function in depression?
Depletion via antihypertensive drugs can cause depression Useful antidepressants increase synaptic monomania cones Post-mortem evidence of reduced serotonin in those with depression Blockade of serotonin synthesis by inhibitor prevents antidepressant effects of MAOIs and TCAs Tryptophan depletion leading to decreased serotonin triggers MDD relapse
40
How do you measure receptors and transmitters in the brain?
PET Injection of radio tracer Tracer binds to specific target
41
What is the issue with measuring the release of cerebral 5-HT?
No suitable tracer has been found | None are sufficiently sensitive to pharmacological challenges