Depression Flashcards

1
Q

What is mood disorder / Affective disorders?

A

where the fundamental disturbance is a change in affect/mood to depression (with or without associated anxiety) or to elation.

The mood change is usually accompanied by a change in the overall level of activity

Most of the other symptoms are either secondary to the change in mood and activity.

Most of these disorders tend to be recurrent

onset of individual episodes can often be related to stressful events or situations.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the criteria for depressive episode?

A
  • 2 weeks of depressive mood and: 4/8 min of following:
  • insomnia, hypersomnia
  • appetite alterations
  • diminished interest / anhedonia*
  • decreased concentration
  • low energy *
  • guilt
  • psychomotor chances
  • low mood *
  • = core symptoms
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is a major depressive disorder?

What three subtypes are there?

A

If no manic of hypomanic past, then current major depressive episode = longitudinal diagnosis of major depressive disorder -MDD

Can have subtypes:

  • atypical features e.g. sleep, appetite, heightened mood reactivity
  • melancholic features marked psychomotor retardations and anhedonia
  • psychotic features of delusions or hallucinations
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What three biological features are there of depression?

A

Sleep
Libido
Appetite

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What are the core symptoms of depression?

A

Low mood
Anergia
Anhedonia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What psychological symptoms are there of depression?

A

The world
Oneself
The future

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What are the criteria of mania?

A

Decreased need for sleep alongside energy

Distractibility

Grandiosity

Flight of ideas or racing thoughts

pressure speech

increased goal directed activities / agitation

impulsive behaviour e.g. financial or sexual in nature

3 or more with either euphoria or irritable mood = mania / bipolar

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

How is unspecified bipolar disorder decided on?

A

Less than 4 days symptoms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Can someone have psychotic features and hypomania?

A

No, hypomania cannot be diagnosed alongside psychotic features

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Can you diagnose someone with bipolar disorder if it is caused by antidepressants?

A

yes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is cyclothymia?

A

Mild form of bipolar:

Most people’s symptoms are mild enough that they do not seek mental health treatment, or the emotional highs feel nice, so they do not realise there’s anything wrong or want to seek help.

This means cyclothymia often goes undiagnosed and untreated.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What form of episode do bipolar I people experience first?

A

Depressive followed by mania

  • need to also focus on anxiety in these people.
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Bipolar depression vs unipolar depression?

A
Bipolar = early onset
Unipolar = later 20s
Bipolar = shorter episodes
Unipolar = longer depressive episodes

Bipolar = more frequent episodes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Insight in depression vs mania?

A

Insight preserved in depression

impaired in mania

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What are attention biases?

A

Biases in shifting attention e.g. difficult for depressed people to disengage from negative material

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is memory bias in depression?

A

Preferential recall of negative compared to positive material

17
Q

What is perceptual bias in depression?

A

Increased recognition of negative faces

  • enhanced amygdala response to negative faces

amygdala generally is sensitive to detecting and triggering responses to arousing stimuli, it exhibits a bias towards detecting cues signalling potential threats, like expressions of fear

18
Q

What happened to facial expression recognition when healthy ppl were given antidepressants?

A

Better recognition of happy faces

decreased recognition of fearful faces

19
Q

What is the monoamine deficiency hypothesis?

A

Depressive symptoms arise from insufficient levels of monoamine neurotransmitters serotonin / norepinephrine / dopamine

20
Q

What indirect evidence is there for 5-HT hypofunction in depression?

A
  • The antihypertensive drug reserpine can cause 5-HT depletion and hence depression
  • clinically useful antidepressants all increase synaptic monoamine concentrations
  • post mortem evidence of reduced 5-HT levels in brainstem of those committed suicide
  • lower levels of 5-HT receptors
  • Monoamine oxidase Increase in MDD
  • more on slide 5
21
Q

How can we measure receptors and transmitters in a living human brain?

A

PET imaging:
Positron emission tomography

injection of radioactive pharmaceutical = tracer

tracer binds to specific target e.g. receptor