Depression Flashcards

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1
Q

Associated symptoms of depression

A
Disturbed sleep
Decreased/increased appetite/weight 
Fatigue 
Poor concentration 
Feelings of worthlessness 
Suicidal thoughts
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2
Q

When is seasonal affective disorder diagnosed

A

If the person has episodes of depression which recur annually at the same time each year with remission in between

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3
Q

Which factors may affect the development, course and severity of depression

A
Hx of mental illness 
Past history of mood elevation 
Living conditions and social isolation 
Family history 
Domestic violence/sexual abuse 
Employment and immigration status
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4
Q

Co-morbid conditions associated with depression

A
Alcohol or substance abuse 
Anxiety 
Eating disorders 
Psychotic symptoms 
Dementia
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5
Q

Which questions are important to ask when assessing the risk of suicide

A

Any thoughts about death or suicide?
Do you feel life is not worth living?
Have you made a previous suicide attempt?
Is there a family history of suicide?

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6
Q

What questions should be asked if an individual has said yes to any of the initial suicide assessment questions

A

Have you considered a method?

Do you have access to the materials?

Have you made any preparations?

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7
Q

Risk factors which increase the risk of suicide

A
Previous suicide attempts 
Active mental illness 
Family history of mental disorder 
Male gender 
Being unemployed 
Physical health problems 
Drug/alcohol abuse
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8
Q

Recommended questionnaires for detecting depression and assessing severity

A

PHQ-9
HADS
BDI-II

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9
Q

Interpretation of PHQ-9

A

Max score of 27
Scores of 5, 10, 15 and 20 represent cut off points for mild, moderate, moderately severe and severe depression, respectively

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10
Q

General management of depression in primary care

A

Manage suicide risk
Manage safeguarding concerns
Manage any co-morbid condition associated with depression

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11
Q

Useful contact for managing suicide risk in primary care

A

Crisis Resolution and Home Treatment(CRHT) team for urgent assessment

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12
Q

When should antidepressants be considered for mild-to-moderate depression

A

Avoid routine use
Consider in:
History of moderate or severe depression
Subthreshold depressive symptoms that have persists for a long period
Mild depression that is complicating the care of a chronic physical health problem

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13
Q

Management of mild-to-moderate depression in primary care

A

Low-intensity psychosocial intervention

CBT

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14
Q

What should be evaluated before starting an antidepressant

A

Suicide risk and toxicity in overdose
Risk of anxiety worsening
Explain that antidepressants take time to work and should be continued for at least 6 months following remission of symptoms to reduce risk of relapse

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15
Q

Who does the mental health act allow compulsory admission for

A

People who:

Have a mental disorder of a nature or degree that warrants assessment or treatment in hospital, and

Need to be admitted in the interests of their own health or safety, or for the protection of other people

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16
Q

How long does section 2 allow compulsory admission for

A

Up to 28 days for assessment

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17
Q

How long does section 3 allow compulsory admission for

A

Up to 6 months for treatment

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18
Q

Who does section 2 and 3 of the mental health act require approval from

A

Approved mental health professional, or the person’s nearest relative

Written recommendations from two doctors; one of whom is section 12 approved(psychiatrist) and one who has previous acquaintance with the individual(usually GP)

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19
Q

When is section 4 of the mental health act used and how long does it allow for compulsory admission for?

A

Used in exceptional cases to permit compulsory admission for up to 72 hours if there is urgent necessity, and undesirable delay

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20
Q

Who does section 4 require approval from

A

Requires application from an AMHP(or person’s nearest relative) and just one medical recommendation

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21
Q

Who can use section 136 of the mental health act

A

Used by the police to take people from a public place to a place of safety so they can be assessed

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22
Q

Can young people who have capacity to consent be admitted on the basis of their parents’ consent

A

Young people aged 16 or 17 who have capacity to consent, but refuse to do so, cannot be admitted or kept in hospital for treatment on the basis of parents’ consent

They will need to be formally detained under MHA

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23
Q

Examples of low-intensity psychosocial interventions

A

Individual guided self-help, based on the principles of CBT

Computerised CBT

Structured group-based physical activity programme

24
Q

Examples of high-intensity psychological interventions

A

Individual CBT
Interpersonal therapy
Behavioural activation
Couples therapy

25
Q

First line antidepressant for the first episode of depression

A

SSRI such as citalopram, fluoxetine, paroxetine or sertraline

26
Q

Which SSRI may be preferred if a person has a chronic physical health problem alongside depression

A

Sertraline due to lower risk of drug interactions

27
Q

Which SSRI should be avoided in patients already taking medications that can prolong QT interval

A

Citalopram or escitalopram

28
Q

Organisations that can help with depression

A

MIND

Depression Alliance

29
Q

General advice for an individual receiving SSRIs for treatment

A

To be vigilant for worsening depressive symptoms and suicidal ideas especially when starting and changing meds

Usually takes 2-4 weeks to improve

Not addictive

May experience discontinuation symptoms if they stop taking antidepressants abruptly

30
Q

When should you review someone with depression if they are not considered to be at an increased risk of suicide

A

Arrange an initial review within 2 weeks

Review regularly thereafter - for example, every 2-4 weeks for the first 3 months and if the response to treatment is good, longer review intervals can be considered

31
Q

When should you review someone with depression if they are at an increased risk of suicide, or people aged under 30 years

A

Arrange an initial review within 1 week

Review frequently thereafter until the risk is no longer considered clinically important

32
Q

Next step of treatment if low-intensity psychosocial intervention has not worked for depression

A

High-intensity psychological intervention or an antidepressant

Next step is combination therapy

33
Q

Advice regarding use of St john’s wort in depression

A

Advise to avoid

34
Q

Adverse effects of antidepressants that should be monitored for

A

Suicidal thoughts and suicide attempts
Anxiety, agitation, or insomnia
Hyponatraemia
Sexual dysfunction

35
Q

Symptoms of hyponatraemia

A
Dizziness
Drowsiness 
Confusion 
Nausea 
Muscle cramps 
Seizures
36
Q

Management of hyponatraemia in individuals taking antidepressants

A

Stop the antidepressant
Manage according to severity and duration of symptoms, and state of hydration
After serum sodium levels have normalised, choose another appropriate antidepressant

37
Q

Risk factors for hyponatraemia in individuals taking antidepressants

A
Older age 
Female gender 
Major surgery 
History of hyponatraemia 
Co-therapy with diuretics, NSAIDs etc
Reduced renal function 
Low body weight 
Medical comorbidity
38
Q

Management of sexual dysfunction in depression

A

Watchful waiting
Reducing dose of antidepressant
Drug holidays(missing doses prior to planned sexual activity)
Adjunctive treatment with sildenafil

39
Q

Features of serotonin syndrome

A
Confusion 
Delirium 
Shivering 
Sweating 
Changes in blood pressure 
Myoclonus
40
Q

How should antidepressants be stopped

A

Reduce the dose or frequency gradually over a 4-week period

41
Q

Discontinuation symptoms of antidepressants

A
Restlessness 
Problems sleeping 
Unsteadiness 
Sweating 
Abdominal symptoms 
Altered sensations(Paraesthesia) 
Irritability 
Anxiety
42
Q

What should be co-prescribed if a patient is taking an NSAID along with an SSRI

A

PPI

43
Q

SSRIs in pregnancy

A

Use during the first trimester gives a small increased risk of congenital heart defects

  • Use during the third trimester can result in persistent pulmonary hypertension of the newborn
  • Paroxetine has an increased risk of congenital malformations, particularly in the first trimester
44
Q

What type of antidepressant is rasagiline

A

MAOI

45
Q

Which SSRI has a longer half-life and therefore has a lower risk of inducing withdrawal symptoms

A

Fluoxetine

46
Q

Definition of treatment-resistant depression

A

Persistent depressive symptoms not responsive to two antidepressants for a minimum of 4-6 weeks at therapeutic dose

47
Q

Management of treatment-resistant depression

A
  • Mirtazapine(NaSSA) and venlafaxine(SNRI), or other combinations
  • Augment with an antipsychotic
  • Lithium
  • ECT
48
Q

First line treatment of diabetic neuropathy

A

Duloxetine

49
Q

Side effects of SNRIs

A

Risk of cardiac dysfunction with SNRIs such as venlafaxine + greater risk of toxicity in overdose than SSRIs + seizures

50
Q

Section 5(2) of MHA

A

Detention of a patient already in hospital for up to 72 hours (A&E does not count)

Can be put on by the ward doctor or an Approved Clinician

51
Q

Section 5(4) of MHA

A

Any authorised psychiatric nurse may use force to detain a voluntary ‘mental’ patient who is taking their own discharge against medical advice, if such a discharge would be likely to involve serious harm to the patient (eg, suicide) or to others.

During the 6 hours, the nurse must find the necessary personnel to sign a Section 5(2) application or allow the patient’s discharge.

52
Q

Section 2 of MHA

A

The period of assessment (and treatment) lasts for up to 28 days and is not renewable.
Patients’ appeals must be sent within 14 days to the mental health tribunal (composed of a doctor, lay person and lawyer).

An AMHP or the NR makes the application on the recommendation of two doctors, one of whom is ‘approved’ under Section 12(2) of the Act (in practice a consultant psychiatrist or a specialist registrar of sufficient experience). The second medical recommendation is given by a doctor who knows the patient personally in a professional capacity.

53
Q

Section 3 of MHA

A

Detention for treatment for 6 months. The exact mental disorder must be stated.

Detention is renewable for a further six months (annually thereafter).
Two doctors must sign the appropriate forms and know why treatment in the community is contra-indicated. They must have seen the patient within 24 hours and there may not be more than five clear days between the time the first doctor saw the patient and the time when the second doctor saw them. They must state that treatment is likely to benefit the patient, or prevent deterioration; or, that it is necessary for the health or safety of the patient or the protection of others. The AMHP has 14 days after the second doctor has signed their recommendation in which to make an application to hospital.

54
Q

Section 136 of MHA

A

For up to 72 hours

Allows police to arrest a person ‘in a place to which the public has access’ and who is believed to be suffering from a mental disorder.

The patient must be conveyed to a ‘place of safety’ (usually a designated A&E department) for assessment by a doctor (usually a psychiatrist) and an approved social worker.

The patient must be discharged after assessment or detained under Section 2 or 3. The patient may also accept the offer of a voluntary admission into hospital.

55
Q

SSRI discontinuation symptoms

A
increased mood change
restlessness
difficulty sleeping
unsteadiness
sweating
gastrointestinal symptoms: pain, cramping, diarrhoea, vomiting
paraesthesia
56
Q

How should SSRIs be reduced

A

Over 4 week period