Deposits in Glomerular Nephritides

Question 1

minimal change disease - site of immune complex deposits?

Answer 1

*NO immune complex deposits
*IF negative

Question 2

membranous nephropathy - site of immune complex deposits?

Answer 2

*subepithelial immune deposits, “spike and dome”
*IF: granular staining, IgG/C3

Question 3

FSGS - site of immune complex deposits?

Answer 3

*NO immune complex deposits
*nonspecific IF IgM/C3

Question 4

diabetic glomerulonephropathy - site of immune complex deposits?

Answer 4

*NO immune complex deposits
*Kimmelstein-Wilson nodules
*IF nonspecific IgG

Question 5

amyloid nephropathy - site of immune complex deposits?

Answer 5

*NO immune complex deposits
*cotton candy deposition amyloid protein fibrils
*IF: lambda light chains > kappa

Question 6

MPGN - site of immune complex deposits?

Answer 6

*subendothelial deposits
*IF: IgG, C3, C1q/C4

Question 7

dense deposit disease - site of immune complex deposits?

Answer 7

*irregular ribbon-like electron dense deposits in GBM
*IF: granular/linear C3

Question 8

PIGN - site of immune complex deposits?

Answer 8

*subepithelial hump-shaped deposits, + mesangial & subendothelial
*IF: IgG/C3 in GBM

Question 9

IgA nephropathy - site of immune complex deposits?

Answer 9

*mesangial deposits +/- subendothelial, subepithelial
*IF: diffuse global IgA lambda > kappa, C3

Question 10

lupus nephropathy - site of immune complex deposits?

Answer 10

*subendothelial, mesangial, subepithelial deposits
*IF: “full house” appearance