Introduction to Renal Pathology

Question 1

normal glomerulus with PAS stain (image)

Answer 1

Question 2

compartments of the glomerulus (image)

Answer 2

1. endocapillary - contains the circulating blood
2. extracapillary - contains the filtrate that is flowing into Bowman’s Space
3. mesangial - composed of cells + their mesangial matrix (made of collagen IV)

Question 3

normal glomerulus with PAMS (Jones Silver) stain (image)

Answer 3

*stains basement membranes black

Question 4

normal glomerulus with trichrome stain (image)

Answer 4

*stains collagen blue, cytoplasm red, and nuclei black

Question 5

mesangial cells - patterns of injury

Answer 5

1. expansion
2. proliferation (hypercellularity)
3. mesnagiolysis

Question 6

capillary patterns of injury

Answer 6

1. endocapillary hypercellularity
2. extracapillary hypercellularity (crescents)

Question 7

membranous patterns of injury

Answer 7

1. capillary wall thickening
2. capillary wall irregularity (“spikes and domes”)
3. capillary wall replication

Question 8

glomerulosclerosis patterns of injury

Answer 8

1. segmental
2. global (whole glomerulus)

can be focal (<50% sclerosed glomeruli) or diffuse (>50% sclerosed glomeruli)

Question 9

normal glomerulus with transmission electron microscopy (image)

Answer 9