Deposition in mechanism

Question 1

Dust

Answer 1

Solid particles formed by mechanical disintegration of material

Question 2

Smoke

Answer 2

Visible aerosol resulting from incomplete combustion

Question 3

Fog or mist

Answer 3

Liquid particles formed by condensation or atomisation

Question 4

Aerodynamic properties depend on

Answer 4

Size, shape, density

Question 5

Target site for local action

Answer 5

Bronchioles

Question 6

Target site for systemic drug delivery

Answer 6

Respiratory bronchioles and alveoli

Question 7

Factors controlling aerosol deposition

Answer 7

Aerosol properties, mode of inhalation, patient relating factors

Question 8

Particle deposition mechanism

Answer 8

Inertial impaction, gravitational sedimentation, diffusion, interception, electrostatic deposition

Question 9

Inertial impaction is caused by

Answer 9

tendency of particles to continue to move in straight line

Question 10

Inertial impaction mainly occurs at

Answer 10

oropharynx, larynx (turbulence) or at bifurcations

Question 11

Gravitation sedimentation occurs when

Answer 11

air velocity in respiratory tract is low and residence time is high

Question 12

Diffusion is important for

Answer 12

deposition in terminal bronchioles and alveolar regions , high residence time increases diffusion deposition efficiency

Question 13

Interception is deposition where

Answer 13

particles contact walls

Question 14

Electrostatic deposition

Answer 14

Charged particles repel - increase in migration towards airway walls, can increase efficiency of deposition