Dental Implants in the Medically Compromised PT. Flashcards
When should the following questions be considered? :
Is there any relative or absolute contraindication for dental implant surgery in this patient for medical reasons?
Does the patient have any medical condition or take any medications that jeopardizes the normal osseointegration and healing of the implant surgery ?
Initial Consult
Implant surgery is an______ procedure
elective
______ ______ for appropriate control of the disease process
Medical consultation
What does the acronym MRONJ mean?
Medication Related Osteonecrosis of the Jaws
- Diabetes Mellitus
- Osteoporosis
- Head and Neck Cancer irradiation
- Patients at risk for developing MRONJ (Medication Related Osteonecrosis of the Jaws)
- Congenital Bleeding disorders - - Patients on Oral anticoagulants/Antiplatelet Medication
- Cardiovascular diseases -Corticosteroids - —
- Immunocompromised Patients - -Neuro-Psychiatric Disorders
Medically Compromised Patients Commonly Seen In The Dental Office
- Disorder of glucose metabolism
- Two major type
- Type I: Insulin-dependent - Type II: Non-insulin-dependent (95%)
- New cases: 1.4 million are diagnosed per year
- Increases with age – 90% over 45 y/o
DiabetesMellitus
- Its global prevalence was estimated to be 2.8% in 2000 and is expected to rise to 4.4% in 2030 - 25% end stage renal disease - Leading cause of blindness - 7th leading cause of death
DiabetesMellitus
Hyperglycemia has a negative effect on bone metabolism
What is that called?
Diabetic osteopathy
________ may lead to severe complications
Macro/micro angiopathy, neuropathy, increased risk of infections
Hyperglycemia
t/f: Current literatures support the use of dental implants in diabetic patientswith good metabolic glucose control
true
t/f: Strict glycemic control dental implant treatment is highly recommended before and after
true
A comparable survival rates ____%-____%were reported on dental
implants placed in diabetic patients with good/fair metabolic control.
(85.5 to 100%)
- Prepared by both dentist and endocrinologist - Monitor blood glucose levels
- current level and improvement - Preoperative HbA1c value
- ≤ 7% is ideal; ≤ 8% is acceptable - Others: co-morbidities, restoration of proper oral hygiene, cessation of tobacco, treatment of periodontitis
Preoperative Management of Diabetes Mellitus
Preoperative HbA1c value
- ≤__% is ideal;
7%
Preoperative HbA1c value
≤ _% is acceptable
≤ 8%
_______ _____With a diabetes pt.
- To reduce the potential risk of infections
- Consider antibiotics and antiseptic mouthwashes
- Antibiotics: penicillin, amoxicillin, clindamycin or metronidazole - Antiseptic mouthwashes: Peridex (Chlorhexidine)
- Reinforce supportive therapy/maintenance systems
Preoperative Management
t/f: uncontrolled DM:
NO IMPLANTS until it’s under controlled
Conventional solutions could be good alternative options
Removable dentures OR bridges as fixed prosthesis
true
- Generalized reduction in bone density and alterations in the microstructure of bone
Osteoporosis
t/f: - Not enough evidence to consider osteoporosis as an absolute contraindication for implant placement
true
________ may increase risk of complications in bone augmentation
osteoporosis
t/f: Use of dental implants with modified, hydrophilic surfaces improves success rate in Osteoporosis pt.
true
t/f: - Immediate loading of the dental implants is not recommended
true
_____ & ______ ________
- Account for 6 percent of all malignancies in the US - Surgery and radiation therapy
- 60-80% patients affected by head and neck cancer
have radiation therapy
Head and neck cancer
What areas are impacted by the early effects of Irradiation of Head and Neck Cancer?
Salivary glands, skin, oral mucosa
Late effects of Head & Neck Cancer Irradiation
Bone changes, demineralization, fibrosis, avascular necrosis
- One serious complication of head & neck radiation - Induce vascular insufficiency rather than infection
- Hypocellular, hypovascular and hypoxia
- Non healing wound and dead bone - Mandible or site with radiation ≥ 6500 Rads/65Gy
Osteoradionecrosis
ORN
t/f: “Radiation dose ≥ 55 Gy significantly decreased implant survival.”
true
t/f:
“Better implant survival rate in the mandible (93.3%) than the maxilla (78.9%)”
true
t/f: “An increased implant failure risk (RR 2.74) in irradiated patients”
true
t/f: In patients who are planned to undergoing radiotherapy, place the implants at least 3 weeks (21 days) prior to or at least 9 months after irradiation treatment is recommended
true
t/f: If a pt has irradiation induced mucositis it is a contradiction of dental implants
true
- Antibiotic prophylaxis and strict surgical sepsis. - Render Hyperbaric Oxygen Treatment (HBOT) when the total irradiation dose is ≥ 50 Grays. - Avoid immediate loading and use implant supported prosthesis without mucosal contact
preoperative Management of Irradiated pts.
Interfere with bone turnover at the dental implant interface Increase the risk of developing osteonecrosis of the jaws (ONJ)
MRONJ
Medication Related Osteonecrosis of the Jaws
Current evidence found the higher risk of ONJ for the following situations: (3)
- Intravenous BP
- Prolonged duration
- Posterior areas after implant placement
t/f: Cancer patients treated with intravenous BP are contraindicated for implant placement
true
are oral Bisphosphonates a contraindication for implants?
- Oral BP are not considered a contraindication
- In patients taking oral BP for ≤ 5 years, neither the
short term (1-4 years) implant survival nor the risk of
ONJ seem to be increased.
A ___ ___ has limited evidence in preoperative management of MRONJ:
drug holiday
- Discontinue BP 2 months before and 3 months after surgery for ≥ 4
years in patients taking BP alone or associated with corticosteroids/
anti-angiogenic medication
drug holiday
The following are examples of _____ ______:
- Inherited bleeding disorders
- Von Willebrand Disease
- Hemophilia A and Hemophila B - Medication associated bleeding disorders
- Oral anticoagulants
- Antiplatelet Medication
bleeding disorders
t/f: - Inherited bleeding disorder may increase the risk of hemorrhage during implant surgery. - Not a contraindication for implant survival/success
true
a minimum level of __% Assessment and augmentation of the deficient coagulation factor before surgery if necessary
50%
Operative Management of ____ ______:
- Use local anesthesia with vasoconstrictor (slow injection technique and fine needles) - Use appropriate suturing technique - Use local hemostatic measures to achieve hemostasis
- Use anti-fibrinolytic agents (5% tranexamic
mouthwash) during surgery and up to 7 days post-
surgery
Bleeding Disorder
______ _______ of Bleeding disorder pts. :
- Reduce the risk of the infection
-Use topical antiseptics (chlorhexidine mouthwashes)
or antibiotics - Reduce the risk of postoperative bleeding - Discuss the use of non-steroidal anti-inflammatory
medications for pain management with the physician
post operative
t/f: The patients who are currently taking oral anticoagulants or antiplatelet drugs are at higher risk of hemorrhage during implant surgery
true
- Short half life (12hrs)
- Examples: Pradaxa and Xarelto
- Stopped 1 day before the Implant procedure - Longer half life (20-60hrs)
- Examples: Coumadin
- Risk at developing a thromboembolic episode
Anticoagulants and Antiplatelet medication
Consult the physciain before stopping ____ ___ _______ medications
Anticoagulants and Antiplatelet medication
t/f: Medical interactions increase the anticoagulant effect of Coumadin:
- Antibiotics: amoxicillin, erythromycin,
metronidazole, clarithromycin, ciprofloxacin
- Analgesics: NSAID
true
INR >3-3.5 (contraindication for Implant)??
true
Platelet count
<50,000/mm3
For HIV pts:
Dental implant treatment can be rendered only when……
- The CD4 cell count rates are high
- The patient is on antiretroviral treatment
For HIV + pts, what labs values must be check before surgery?
- CD4 ell count
- Absolute neutrophil count (ANC)
- Platelet count
if a pt has Less than 500/mm³ neutrophil granulocytes present in the blood it is considered a ____ risk of infection
severe
if a pt has More than 1500/mm³ neutrophil granulocytes present in the blood it is considered a ____ risk of infection
normal risk of infection
t/f: - Successful dental implant therapy has been reported in patients receiving organ transplantation (mainly liver and kidney) with long-term cyclosporin therapy
true
Characterized by the presence of several antibody‐ antigen complexes, leading to autoimmune inflammatory processes in many parts of the body
Crohn’s Disease
t/f: “Crohn’s disease showed a significant effect on early
implant failure and resulted in increased, however not
significant, implant loss.”
true
t/f: -Immuno-incompetence is not an contraindication
- Appropriate medical consultation
- Assess the degree of immuno-compromise
- Reduce risk of infections by rendering antibiotic
prophylaxis/antiseptic mouthwashes
true
true or false:
- NOT suitable to place dental implants
- Significant immunosuppression cases
- Eg. Total White Blood Cell count <1,500-3,000/mcL
(Normal: 3,500-10,500/mcL)
true
- Exerts a negative feedback control on the HPA axis
- Suppress corticotropin
releasing hormone(CRH) then
corticotropin(ACTH) secretion - Adrenal atropy and loss of
cortisol secretory capability - Reduce bone density, increase epithelial fragility and immunosuppression - Adrenal Crisis
Long Term Effects of Corticosteroids
t/f: use of systemic glucocorticod might compromise dental implant oseointegration and peri-implant healing.
true
Does dental Implant failure rate and/or surgical morbidity increase in patients under systemic corticosteroids?
NO
No evidence in literature that have been demonstrated it.
t/f; - For dental implant surgery, take regular steroid dose
prior to the surgical procedure “No need to double
the dose of steroids”
true
t/f: No evidence that cardiac disorders are contraindicated - Consider other issues
- The occurrence of bleeding (Hypertension)
- Cardiac ischemia (Coronary artery disease)
true
the following are steps in ____ _____ _____:
- Supplemental oxygen
- Sedation
- Effective local anesthesia with aspiration (limit epinephrine use)
- Minimize duration of appointment - - - Position semi-supine
stress reduction protocol
With cardiac disorders, Only Emergency procedures if MI is within ____ months
2 months
It is important to consider the following for pts with ____ ______.
- Poor oral hygiene
- Oral parafunctions
- Harmful habits
- Behavioral problems
Neuropsychiatric disorders