Dendritic Cells

Question 1

Where are dendritic cells found?

Answer 1

Periphery eg skin

Question 2

What are direct danger signals?

Answer 2

TLR2, TLR4, TLR5 or TLR9

Question 3

How does a DC mature?

Answer 3

Migrates to secondary lymphoid tissue

Question 4

What does CCR7 do?

Answer 4

Stimulate DC maturation

Question 5

What is a mature DC efficient at?

Answer 5

Antigen Presentation

Question 6

What is immature DC efficient at?

Answer 6

Antigen Uptake

Question 7

What is Macropinocytosis?

Answer 7

Large vesicles in plasma membrane which allow uptake of large cells and surrounding fluid.

Question 8

What are the 4 receptors for phagocytosis?

Answer 8

Fc Receptors, C-type lectins, Scavenger receptors and HSP receptors.

Question 9

What are the Fc receptors involved in phagocytosis?

Answer 9

Fc-gamma-RI and FcERI which bind to Fc portion of antibodies

Question 10

What are scavenger receptors?

Answer 10

CD36 bind to apoptotic bodies

Question 11

What are C-type lectins?

Answer 11

Mannose receptor and DEC205 recognise glycosylated antigens

Question 12

What does HSP stand for?

Answer 12

Heat Shock Proteins

Question 13

What do HSPs do?

Answer 13

Recognise Hsc70/gp96 on tumour cells mediate internalisation