B Cell Activation and Response Flashcards
1
Q
Where does B cell maturation occur?
A
Bone Marrow
2
Q
Where do mature B cells go?
A
Lymph nodes and spleen
3
Q
What shape and where is IgM?
A
Pentameric, blood.
4
Q
What shape and where is IgD?
A
Monomeric, serum
5
Q
What shape and where is IgG?
A
Monomeric, Blood/tissue.
6
Q
What shape and where is IgA?
A
Dimeric, Mucosa
7
Q
What shape and where is IgE?
A
Monomeric, bound to mast cells.
8
Q
What do VL domains of immunoglobin consit of?
A
2 beta-sheets bond by a disulphide bond.
9
Q
What does somatic hypermutation require?
A
AID
10
Q
What antigens do B Cells express first?
A
IgM
11
Q
What stimulates expression of IgE
A
IL-4
12
Q
What stimulates expression of IgG
A
IL-4
