Dementia, Parkinson, Alzh

Question 1

WHat is this

Answer 1

Medulloblastoma

Question 2

Early Brain deveopment

Answer 2

Late brain development

Question 4

The (chick) brain

Answer 4

Question 5

Typical vertebrate brain

Answer 5

Question 6

Corpus Striatum

Answer 6

Question 7

Brian cross section

Answer 7

Question 8

Transverse/horizontal/ axial section

Answer 8

Question 9

Midbrain - dorsal section

Answer 9

Forebrain, cerebellum removed on the image

Question 10

midbrain cross section with staining

Answer 10

Question 12

Midbrian with no immunhistochemistry

Answer 12

Question 13

Inputs to the caudate and putamen

Answer 13

Teh caudate and putamen receive inputs from the cortex and substantia nigra (midbrain)

Question 14

Outputs from basal ganglia

Answer 14

Question 15

Describe the basis of GABAergic signalling

Answer 15

The basis of control is GABAergic inhibitory signalling. The GABAergic circuit design means that output is the result of an inhibition of an inhibition: disinhibition.

Question 16

Describe a suimple Basal ganglia circuit

Answer 16

Question 17

Disinhibitory cicuits

Answer 17

Question 18

DIretc pathway of reinforement in basal ganglia

Answer 18

Question 19

Indirect pathway of inhibition of basal ganglia

Answer 19

Question 20

Direct vs indirect pathway

Answer 20

Question 21

hyperdiretc pathway of basal ganglia

Answer 21

Question 22

Motor and non motor loops in brain

Answer 22

Question 23

Parkinson histopathology

Answer 23

Lewy Bodies - an accumulation of -synuclein protein

Question 24

Parkinson disease patho

Answer 24

Get lack of coordinated movements as loose control.

Question 26

Hippocampal anatomy- brain areas assoicated wih declarative memory disorders

Answer 26

Question 27

Hippocampal neuroatomty - ventral view

Answer 27

Question 28

Hippocamapal etymology

Answer 28

Question 29

the evidence of hippocampal function from rodent models

Answer 29

There is a distinction between procedural memory and declarative memory. Rats with lesioned hippocampus falter in the latter.

Question 30

Hippocampal funciton evidence from henry molaison

Answer 30

forever trapped in 1953 as had do hippocampus

Question 31

Hippocampal circuitry

Answer 31

Projections to much of the rest of the brain…

…as befits a structure involved in generating new memories.

Question 32

Hippocampal function

Answer 32

• It is one of the only sites in the adult mammalian brain where adult neurogenesis occurs.
• It has a well-understood circuit architecture exhibiting interesting neuronal behaviour that can be maintained in a slice culture.

Question 33

Long term potentiation (LTP) experiment

Answer 33

• Long term potentiation exhibits the porperty of input specificity
• LTP acts over minutes, hours, months and years

Question 35

Pathiobiology of alzheimers

Answer 35

Question 36

Biomarker vs disease progressions

Answer 36

Answer 37