Dementia Lecture Flashcards
what is dementia?
a group of disorders characterized by development of multiple cog deficits
physiological effects of a medical condition
cog impairment that interferes with ability to fxn at work or at usually activities
t/f: dementia cannot be explained by delirium or a major psychiatric disorder
true
dementia involves impairment in 1 or more of what cognitive domains?
complex attention
executive fxn
learning and memory
language
perceptual
motor
social
describe the onset of dementia?
chronic onset, usually gradual
if there was a sudden onset of dementia sx, what is more likely the reason?
something like a stroke
what are the common characteristics of disease progression in dementia?
memory and language probs
IADL difficulties
visuospatial probs
disorientation to place and time
delusions, depression
short-tempered, hostile
lose control of bodily fxns
what conditions may mimic dementia?
delirium
depression
med side effects
infections (UTI, pneumonia)
thyroid conditions
vitamin deficiencies
excessive alcohol use
age-related cog decline
mild cog impairment
delirium
depression
what is involved in cognition?
complex attention
learning and memory
executive fxn
language
perceptual-motor
social cognition
what brain structural changes are involved in normal cognitive aging?
atrophy
loss of neurons
protein-forming plaques
tangles created by dead cells
what behavioral changes involved in normal cognitive aging?
slowing of cog processing
decline in word-finding
memory loss
making occasional error managing finances/household bills
word finding errors
misplacing things from time to time
may see personality changes as memory loss progresses
what are the key differences bw normal changes and sx of cognitive impairment? (KNOW THIS)
in normal changes, the pt is able to fxn independently, recall episodes of forgetfulness, doesn’t get lost in familiar places, occasionally has work finding difficulty, but not trouble holding convo, and has intact judgement/decision-making
in cog impairment, they have difficulty with simple tasks, unable to recall episodes of forgetfulness, get lost in familiar places, frequently forget words, repeat stories and phrases, and have trouble with decision making
in pre-clinical AD, do pts have brain changes that indicate AD?
they may
what are examples of AD brain changes?
abnormally high levels of beta-amyloid and tau and decreased glucose metabolism on PET scans
changes in tau protein in CSF
in pre-clinical AD, even though brain changes may be present, why can the individual fxn normally?
bc the brain compensates
what is mild cognitive impairment (MCI)?
a new memory complaint with objective findings of impairment in episodic memory, normal cog fxns, no substantial life interferences, but may have biomarkers for AD
ppl with MCI have an increased risk of developing what?
AD dementia
do all ppl with MCI develop AD?
nope
those with what type of MCI are more likely to develop dementia due to AD?
amnestic (memory) type
what are the s/s of MCI?
missing appointments
asking the same question repeatedly
forgetting names, places, and common items
difficulty following instructions
changes in mood
confusion regarding dates and time
apathy
what are the three Ds?
dementia
delirium
depression
what is the difference bw AD and dementia?
AD is a specific brain disease that accounts for a large % of dementia
dementia is a general term for sx like decline in memory, reasoning, or other thinking skills
what are the greatest risk factors for AD?
age
genetics
fam hx
what age group has the highest % of ppl with AD?
those over 85 yo
what gene is a possible risk factor for AD?
APOE-e4 gene