Dementia Flashcards
Frontotemporal dementia is also known as
Pick’s Dz
Extracellular plaques
amyloid
Intracellular tangles
tau
These deficits are associated with cognitive impairment, agitation, aggression, especially in nucleus basalis, hippocampus, and frontotemporal regions
Cholinergic deficits
These deficits are associated with depression, agitation, aggression and impulse dsycontrol esp with cell loss in raphe nucleus and long 5-HT transporter gene
Serotonergic deficits
These deficits may impact sensitivity to developing spontaneous and drug-induced movement disorders
Dopaminergic deficits
Dementia is now called
Neurocognitive Disorder
*DSMV
Executive functioning is not included in this exam
Mini Mental Exam
Neurocognitive disorders are often noticed first how?
Activities of Daily Living
Pts self-report this impairment
Mild Cognitive Impairement
60-70% of dementias. Uncommon b4 60. Rises steeply after 60
Alzheimer’s
Often misdiagnosed as Alzheimer’s
Vascular dementia
If you suspect dementia, start with MME and then move to which test?
MOCA
Sudden behavior changes, 40-60yo, loss of ability to communicate effectively, very rare
Frontotemporal dementia
Visual hallucinations. Cognitive impairment first, followed by motor impairment
Lewy body dementia
Caused by build up of apha synuclein
Lewy body dementia
Motor impairment first, followed by cognitive impairment
Parkinson’s
Most important skill before giving a cognitive assessment tool
Build repoire!
Score range for MMSE
0 to 30
MMSE Normal Cognitive Fxn
27 to 30
MMSE Mild Cognitive Impairment
21 to 26
MMSE Moderate Cognitive Impairment
11 to 20
MMSE Severe Cognitive Impairment
0 to 10
Gold standard for Cognitive Assessment
MMSE
10 mins to administer
MMSE
Cutoff Score for MMSe
24/30
More sensitive than MMSE; use if concern for mild cognitive impairment
MOCA
MOCA Normal Cognitive Fxn
> 26
MOCA Cognitive Impairment Avg
22
MOCA Alzheimer’s Avg
16
Use for triage only
Mini Cog
3-5 mins, good executive fxn assessment, not affected by language or education level
Mini Cog
spec = 99% sens = 93%
“10 past 11”
Mini Cog
recall 3 words
Mini Cog
If they recall 1 or 2 words, then . . .
Look at the clock
Abnormal clock + 1 or 2 words recall = ?
Suggest cognition deficit according to MiniCog
Cognitive reserve means
lots of resilience to behavior problems seen in cognitive impairment
Can do normal motor memory routine activities
Macro
These impairments show during stress
Micro
Driving test can tell difference between these two things
Macro vs Micro
This exam is not diagnostic
MIni Cog
Risk factors for Alzheimer’s
Increased age, female, Bad brains, other Dz, Mental illness
Alzheimer’s genes
Chromosomes 1, 10, 12, 14, 19 (APOE e4), 21
Donepezil (Aricept)
Rivastigmine (Exelon patch)
Galantamine (Razadyne)
Acetylcholinesterase inhibitors
Memantine (Namenda)
NMDA antagonist
*glutamate
2 NTs needed for learning and memory
glutamate and Ach
Remember: AChEI’s have the potential to increase pulmonary secretions slow hear rate via
peripheral cholinergic activation
How do you give drugs
Give low, go slow
When giving antipsychotics you must . .
Document
*There is a BBW