dementia Flashcards
what is a syndrome
a group of collated symptoms
is dementia a syndrome
yes
what are the symptoms associated with dementia
memory loss
cognitive decline
change in mood
change in personality
impaired thinking
loss of skill
what are four causes of dementia
alzheimers
vascular
lewy body
frontotemporal
what is alzheimers
build up of amyloid plaques
what is vascular dementia
reduced blood flow to the brain
what is lewy body
build up of lewy body
what is frontotemporal dementia
group of disorders that cause damage to the brain
what are some examples of diseases that cause dementia
traumatic brain injury
substance induced
HIV
Parkinsons
Huntingtons
what symptoms do we associate with mild alzheimers
forgetful
short term memory loss
repititive questions
impaired dexterity
what symptoms do we associated with moderate alzzheimers
aphasia
dysexecutive syndrome
transition in care
what do we associate with severe alzheimers
agitation
altered sleep patterns
total dependance
what non pharmacological treatment options can we offer to mild and moderate alzheimers
CBT
reminescense therapy
cognitive rehab
occupational support
what is one of the most important channels in alzheimers
acetylcholine channels
what is aalzheimers caused by
breakdown of cholingergic neurons that leads to cognitive impairment
what is the firstline treatment for mild - mod alzheimers
acetylcholine esterase inhibitors
what is donepezzils mechanism of action
reversibly inhibits aacetylcholine esterase preventing the brreakdown of cchlongergic nuerons preventing as much cognitive impairment
what is the ddose of donepezils
5mg at night for 1 months
then
10mg if needed
what are the cautions of donepezil
copd
asthma
how long does it take for donepezil to reach a steady state
3 weeks
what is donepezil metabolized by
cyp450
what is the half life of donepezil
70 hours
what is a major side effect of donepezil
qt prolongattion
what are the other side effects of donepezil
gi
dizzy
insomnia
abnormal dream
