Dementia

Question 1

First-line in mild-moderate Alzheimer’s dementia?

Answer 1

Acetylcholinesterase inhibitors

Question 2

First-line in severe Alzheimer’s dementia?

Answer 2

Memantine- NMDA channel blocker

Question 3

Second-line for moderate Alzheimer’s dementia if alectylcholinesterase inhibitors are not tolerated?

Answer 3

Mematine

Question 4

What type of dememntias should acetlycholineesterase inhibitors and memantine not be used in?

Answer 4

Vascular disease if not accompainied with parkinson’s dementia or alzherimer’s and frontotemporal dementia

Question 5

First-line for Lewy body dementia in mild-moderate disease?

Answer 5

Donepezil or Rivastigmine

Question 6

Second-line for Lewy body dementia in mild-moderate disease?

Answer 6

Galantamine

Question 7

What condition is memantine cautioned in?

Answer 7

Epilepsy/ history of seziures

Question 8

Why are anti-psychotics not recommended in dementia?

Answer 8

Small increase in stroke risk and risk of death when used in dementia.

Question 9

In which patient group are acetylcholinesterase inhibitors STOPP criteria in the elderly?

Answer 9

Those with marked bradycardia

Question 10

Which type of arrythmias are acetylcholinesterase inhibitors cautioned in?

Answer 10

Those with supraventricular conduction abnormalities and sick sinus sydrome

Question 11

Which respiratory conditions are acetylcholinesterase inhibitors cautioned in?

Answer 11

Asthma and COPD

Question 12

Which gastrointestinal conditions are acetlycholinesterase inhibitors cautioned in?

Answer 12

Susceptibility to peptic ulcers

Question 13

When can memantine be initiated in primary care?

Answer 13

If patient is taking acetylcholinesterase inhibitors prescribed by a specialist and memantine is to be added to treatment due to disease progression.