Delirium Flashcards

1
Q

what are the symptoms of delirium

A

impairment of consciousness - cloudiness, drowsiness, sopor (abnormally deep sleep), coma

disturbance of cognition- disorientation, impaired memory attention and thinking, perceptual disturbance- hallucinations and illusions (commonly visual)

psychomotor (hyperalert/active- agitated, disorientated, hallucinations, delusions, sometimes aggressive or hypoalter/active- confusion sedation or mixed)

disturbance of sleep-wake cycle- insomnia, sleep loss, reversal of sleep cycle, nocturnal worsening of symptoms- sundowning, disturbing dreams and nightmares

emotional disturbances- anxiety, fear, irritability, euphoria, apathy, perplexity, aggression

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2
Q

what is the onset and course of delirium like

A

rapid onset
fluctuates
lasts days to months depending on cause

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3
Q

what can cause delirium

A

anything

more likely to get it if older/ more ill

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4
Q

what drugs can cause delirium

A
anticholinergic agents 
anticonvulsants 
antiparkinsonian drugs 
steroids
cimetidine (H2 antagonist)
opiates
sedatives
alcohol 
illicit drugs
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5
Q

withdrawal from what commonly causes delirium

A

alcohol
sedatives (benzos)
barbiturates
illicit drugs

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6
Q

what seizures condition can cause delirium

A

epilepsy

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7
Q

does delirium have to have an identifiable cause to be diagnosed

A

no

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8
Q

sudden onset of confused state= what until proven otherwise

A

delirium

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9
Q

what are the risk factors for delirium

A
old age 
cognitive deficit- dementia
existing sensory deficit- deafness/ blindness 
previous episode 
preoperative 
extremes in sensory experience (hypo/hyperthermia)
immobility 
social isolation 
new environment 
stress
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10
Q

what investigations into delirium

A

history and full exam
4AT screening test
Ix for cause: urinalysis, bloods, TFT, LFTs, CRPs, B12 and folate, CXR, MRI/CT brain

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11
Q

what is the management for delirium

A

identify and treat cause - sedation may be necessary to allow exams and investigations
begin treatment ASAP

manage environment and provide support- educate staff, reality orientate (communication, clock, calendar), correct sensory impairments, bright sideroom, reduce unnecessary noise, remove unsafe objects, ensure basic needs met, reassure patient- will be frightened

prescribe- benzos for alcohol withdrawal, antipsychotics (haloperidol 1-10mg)- will not treat delirium but can help if agitated or distressed

review frequently (can improve/worsen quickly - suffer seiures, injuries, sudden death)

repeat cognitive assessment to avoid misdiagnosis of dementia

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12
Q

why should you be careful about sedation in delirium

A

can worse it by increasing confusion and unsteadiness

if patient scared reassure instead of prescribe

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13
Q

how can you manage the environment for a patient with delirium

A
quiet side room 
constant orientation- clock, calendar
encourage minimal staff changes
well lit 
remove unnecessary equipment
meet basic needs
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14
Q

what drugs to treat distress in delirium

A

haloperidol 0.5-5 mg orally than IM, up to 10mg in 24 hours

lorazepam (NOT DIAZEPAM) 0.5-2mg up to 2x in 24 hours for parkinsons, lewy body dementia, neuroleptic sensitivity

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15
Q

what is the prognosis of delirium

A

1-4 weeks, longer in elderly

minority can become chronic

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16
Q

what are the features of hyperactive delirium

A

common in elderly +/- cognitive impairment with recent injury
sudden onset confusion, agitation, restlessness
fine during day, overactive in the evening, awake overnight
disruptive behaviour
delusion/ hallucinations of persecution

17
Q

what are the features of hypoactive delirium

A

same demographic as hyper
becomes sudden quiet, withdrawn and sleepy
fluctuates throughout the day
doesnt eat, drink, tend to care
wont engage in rehabilitation
thought of as ‘depressed, unmotivated, lazy, uncooperative’

18
Q

what is the most common type of delirium

A

mixed (hypo and hyper)
will vary wildly throughout day
asleep all day, disruptive at night

19
Q

what is the most common neuropyschiatric complication of a stroke

A

post stroke depression

up to 1/3rd of patients will have a major depression that affects cognition, motivation, rehabilitation

20
Q

what psychiatric condition is common after an MI

A

post MI depression

21
Q

what are the features of limbic encephalitis

A

middle aged patients
sub acute memory loss, ‘panic attacks’/ jerky movements= partial seizures
in non neoplastic causes prognosis is good

22
Q

what is found on investigations in limbic encephalitis

A

MRI brain- hyper intensity medidal temporal structures +/- cortical ribboning
mild hyponatraemia
presence of VGKC antibodies (this is diagnostic)

23
Q

what are the features of NMDA receptor antibody encephalitis

A

young women, avg age 22
associated ovarian teratoma
prodrome - isolated psych symptoms, global impairment/ movement disorder