Delirium Flashcards

1
Q

Types of delirium

A

Hypoactive (40%)
Hyperactive
Mixed

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2
Q

Describe hypoactive delirium

A

Apathy
Withdrawal
Lethargy
Reduced motor activity

Often goes unrecognised or mistaken as depression

Higher hospital stays and risk of pressure sores

he patient is quiet, withdrawn, lacks initiative and responds poorly to interaction

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3
Q

Describe hyperactive delirium

A

Increased motor activity
Agitation
Hallucinations
Challenging behavior

More likely to be recognised

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4
Q

Describe mixed delirium

A

Fluctuations between hypo and hyperactive, often during the course of a day

Sleep-wake disturbance

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5
Q

Aetiology of delirium

A
Infection
Withdrawal
Acute metabolic
Trauma
CNS pathology
Hypoxia
Deficiencies
Endocrine
Acute vascular
Toxin
Heavy metal
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6
Q

DSM-5 criteria of delirium

A

Disturbance of consciousness with reduced ability to focus, sustain or shift attention

Change in cognition that develops over a short period of time that is not better accounted for by a pre-existing, established or evolving dementia

Tendency to fluctuate during the course of the day, with disturbance of the sleep wake cycle

Evidence from history, examinations or investigations that the delirium is a direct consequence of a general medical condition, drug withdrawal or intoxication

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7
Q

Describe what disturbance of consciousness means

A

reduced attention, which is the ability to focus, sustain or shift mental focus:
Distractibility
Drowsiness
Reduced vigilance

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8
Q

Other associated features of delirium

A

Delusions (fleeting, often paranoid, lack logic)

Emotional - anxiety, fear, deprsession

Motor - slowness, restlessness, agitation

Hallucinations - often formed

Cognitive deficits

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9
Q

Which cognitive deficits may be associated with delirium

A

Language difficulties: word finding

Speech - slurred, mumbling, incoherent or disorganised

Memory dysfunction - marked short-term memory impairment, disorientation to PPT

Perceptions - misinterpretationss, illusions, delusions and/or visual or auditory hallucinations

Constructional disability - cannot copy a cube

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10
Q

Clinical characteristics of delirium

A

Develops acutely (hrs to days)

Characterised by fluctuating level of consciousness

Reduced ability to maintain attention

Agitation or hyper-somnolence

Extreme emotional lability - crying/laughing

Cognitive deficits can occur

AMT < 8/10

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11
Q

Which examinations may help in assessing delirium?

A

Assess conscious level: GCS or AVPU

Cognitive function: AMT (<8 is abnormal)

Infection screen

Nutrition and hydration assessment

Constipation (rule out urinary retention and constipation - Abdo exam and DRE). Consider post-void bladder scan

Neurology - perform exam, including speech

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12
Q

What is the Confusion Assessment Method (CAM)

A

Assess 4 features:

Acute onset and fluctuating course (ask family members/nurse)

Inattention (easily distracted/cannot keep track)

Disorganised thinking (including slurred speech)

Altered level of consciousness (alert, vigilant, lethargic, stupor, coma)

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13
Q

What are the predisposing RF for delirium

A
Dementia
Cognitive impairment
Frailty
Multiple co-morbidities
>65yrs
Sensory impairment (eg. vision)
Current hip fracture
Severe illness
Polypharmacy
Malnutrition
Alcohol excess
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14
Q

What are precipitating risk factors for delirium?

A
Drug initiation/withdrawal
Acute brain disease
Surgery
Metabolic abnormalities
Systemic infection
UTI
Hyponatraemia
Hypoxaemia
Shock
Anaemia
Pain
Orthopaedic or cardiac surgery
ICU admission
High number of hospital procedures
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15
Q

Ways of trying to prevent delirium

A

Keep orientated
Promote the familiar

Glasses, light and hearing aid for vision etc

Keep hydrated and well fed

REduce medication (avoid anti-cholinergic drugs and opiates)

Keep mobile and active

Promote night time sleep

Minimise provocation (noise, tubes, restraints)

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16
Q

Investigations in delirium

A
FBC
TFT
LFT
U and E
Glucose
CRP
ECG
Urinalysis
CXR
Lumbar puncture
CT head
EEG
MRI head
Specific cultures
ABG
17
Q

What are the 4 main elements of managing delirium?

A

Identify and treat underlying cause

Management of the symptoms

Prevent complications

Patient and relative explanation

18
Q

Which underlying causes of delirium can be treated

A

Remove offending medication

Treat infection

Correct hypoxia and metabolic derangement

19
Q

How can the symptoms of delirium be managed

A
Optimal environment (quite, orientation cues)
Clocks, mealtimes

Analgesia, but avoid opiates if possible

Maintain hydration and nutrition

Good sleep hygiene (avoid sleep during day, avoid stimulants and too much fluid before bed)

Encourage attendance of relatives

1 to 1 nursing care available?

Keep sedative use to a minimum (agitation often has underlying cause such as constipation, pain, frustration, hallucinations)

Avoid agreeing with rambling speech by tactfully disagreeing (changing the subject while acknowledging feelings but ignoring content)

20
Q

What is the relevance of sedative with regards to delirium

A

Can precipitate it

2 functions:
Rapid tranquilisation of an agitated patient if there is an immediate risk of harm or danger

Short-term control of distress: only use ONE drug and start at the lowest dose possible (Haloperidol IV or Lorazepam)

21
Q

Which pharmacological agents can be used in delirium

A

Haloperidol 0.5mg BD, unless PD or Lewy body dementia

Olanzapine may be used
Lorazepam for rapid tranquilisation

22
Q

What is the recovery rate of delirium

A

Slow..
25% persist at 3 months

20% never recover