DEGRADACION DE COLAGENO Flashcards

APRENDER

1
Q

RADICALES LIBRES DE MAYOR A MENOR

A

OXIGENO
NITROGENO
CARBONO

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2
Q

QUE HACEN LOS RADICALES

A

ROBAN ELECTRONES DE PROTEINAS Y LA DESESTABILIZA

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3
Q

PATOLOGIA CAUSADA POR MUCHOS RADICALES LIBRES

A

ESTRESOXIDATIVO

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4
Q

ANTIOXIDANTES

A

VITAMINA E C A

NATURALES
GLUTATION
OXIDASA

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5
Q

PATOLOGIA POR EXCESO DE VITAMINAS LIPOSOLUBLES ACUMULADAS

A

HIPERVITAMINOSAS

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6
Q

tipos de degradacion

A

proteolitica

fagocitica

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7
Q

tejido donde actuan las metaloproteinasas y celulas

A

tejido conjuntivo
fibroblastos y condrocitos
monocitos neutrofilos macrofagos

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8
Q

tipos de metaloproteinasas (familias)

A
colagenasas
gelatinasas
estromalisinas
tipo membranales 
otras
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9
Q

que es endopeptidasa

A

cortar aminoacidos intermedios

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10
Q

que es exopeptidasa

A

cortar aminoacidos de uno en uno (extremos)

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11
Q

dominios de una enzima

A
central catalitico (zinc)
propeptido (aminoterminal)
hemopexina (inhibidor TIMP)
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12
Q

QUE DEGRADAN LAS COLAGENASAS

MMP 1,8,13

A

DESNATURALIZAN EL COLAGENO
TIPO 1 2 3
AYUDAN A LA CICATRIZACION

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13
Q

QUE DEGRADANLAS GELTINASAS

2,9

A

DEGRADAN EL COLAGENO DESNATURALIZADO

AYUDAN EN PROCESO INFLAMATORIO

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14
Q

QUE DEGRADAN LAS ESTROMALISINAS

A
DEGRADAN PROTEOGLUCANOS
DESNATURALIZADO 
MATRILISINAS:
COLAGENO TIPO 4
METALOELASTASAS:
ELASTINA
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15
Q

QUE DEGRADAN LAS TIPO MEMBRANALES

14,15,16,17,24,25

A

DEGRADAN CELULAS NEOPLASICAS

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16
Q

MMP OTRAS

A

19,20,23,27

17
Q

PATOLOGIAS RELACIONADAS CON EL COLAGENO

A

ARTRITIS REUMATOIDE

OSTEOPOROSIS