Definitions and mapping

Question 1

What is a telomere?

Answer 1

Repeated sequence at ends of chromosomes

Question 2

What are polytene chromosomes?

Answer 2

Oversized chromosomes developed from normal ones

In drosophila salivary glands

Question 3

What are the three methods of mapping chromosomes?

Answer 3

• Fluorescent in-situ hybridisation
• Somatic cell hybridisation
• Genome wide association study

Question 4

What is FISH?

Answer 4

Fluorescent in-situ hybridisation

• Use structure of protein to work out gene
• Complementary fluorescent dna probe used to identify location

Question 5

What is a GWAS? Give an example

Answer 5

Genome wide association study

• Many different genomes to work out which genes do what
• Tests if any particular traits are associated with a particular genetic variant

International Hapmap Project- to develop a haplotype map of the human genome to describe patterns of genetic variation such as skin colour.