Definitions Flashcards
Genome
All the genetic material in a single cell from an organism
Human genome project
A project undertaken to decipher the sequence if bases in the human genome in order to gain a better understanding of the way genes control our genotype
Genotype
Genetic make up of an organism- describes the organism in terms of the alleles it contains
Dystrophin
Largest human gene- 2.4million bases long
Glial cell
Cell found only in the nervous system, which do not conduct action potentials. Provide nutrients and insulation, & aid repair of neurones.
Threshold potential
A specific membrane potential which opens voltage-gated channels. -50mV
Mono amine oxidase
An enzyme which catalyses the break down of a neurotransmitter in the brain involve in the regulation of behaviour
Cambium
Meristem found between the xylem and phloem of vascular bundles
Rods
Light sensitive cells in the retina, responsible for black and white vision. They work better in dim light
Cones
Found in the vertebrate retina- responsible for colour vision
Brain stem
The portion of the vertebrate brain between the spinal cord and the forebrain
Midbrain
Relays auditory informations to the temporal lobe and visual info to the occipital lobe
Selegiline
A drug which inhibits mono amine oxidase and thus the break down of dopamine does not occur
Dopamine agonist
A drug which mimics dopamine and binds to the dopamine receptors- thus triggering an action potential
5-HTT gene
Gene that codes for transporter protein that controls the reputable of serotonin into presynaptic neurones. Ppl with a short version are more likely to develop depression
Pharmacogenomics
The study of why some drugs have different effects on ppl- suspected to be due to different SNP’s
Single nucleotide polymorphisms
DNA sequence variation involving 1bp mutations locations may reveal causes of some inherited diseases
Transgenic
An organism which has been genetically modified to contain a desired gene.
Candidate gene
A gene that may cause a particular disease
Average human gene contains how many bases?
3000
Human genome contains how many bases? How many genes?
3,200,000,000 bases and 20,000-25,000 genes
Function of ApoE gene
Controls production of a lipoprotein used in the repair of cell membranes
Drug target
Specific molecule that a drug interacts with to bring about its effect
Proteomics
Study of structure and fiction of proteins in an organism
Muscle fibre
A single muscle cell surrounded by a cell surface membrane
Striated muscle
Muscle that usually consists of sheets of mononuleated cells connected to the autonomic nervous system
Miyofibrils
Specialised muscle found in the heart; striped and interconnected. Does not fatigue
Total daily expenditure
Amount of energy needed for an active body, most of which is used in muscle contraction